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255 Pre-, pro- and synbiotics 12 Lactobacillus reuteri Coccorullo  et al . evaluated the effect of  Lactobacillus reuteri  (DSM 17938) versus placebo in 44 infants with FC. 24 The authors stated that  L. reuteri  significantly increased the frequency of bowel movements compared with placebo at 2, 4 and 8 weeks. However, results were graphically presented without reporting absolute numbers. Lactobacillus casei rhamnosus Another RCT investigated the effect of Lactobacillus casei rhamnosus  (Lcr35), comparing this with that of magnesium oxide (MgO) and placebo in 41 children. 25 We will not report on the placebo arm, since this arm contained less than 10 children. There was no significant difference indefecation frequency between the Lcr35 group and theMgOgroup. Abdominal pain was significantly less prevalent in the Lcr35 group compared to the MgO group; mean number of episodes of abdominal pain during the 4 weeks of treatment: Lcr35: 1.9 ± 1.6 vs MgO: 4.8 ± 3.7 ( P = .04). Bifidobacterium lactis Tabbers  et al.  studied the use of fermented milk, containing  Bifidobacterium lactis DN-173 010 compared with a non-fermented milk control product in 148 children. 19 The defecation frequency increased notably in both groups, but therewas no significant difference between both groups. Other outcome measures such as fecal incontinence, painful defecation and abdominal pain also did not show any significant differences. Bifidobacterium longum In a crossover trial comparing yogurt containing  Bifidobacterium longum  with yoghurt alone in 59 children 26 , the authors reported that overall a significant difference was found for defecation frequency, painful defecation and abdominal pain between both groups. However, aside from the P -values, the numeric data to support these statements were not provided. Multispecies Probiotics Sadeghzadeh  et al.  studied the effect of a combination of seven probiotics with placebo alongside the use of lactulose in 48 children. 23 The authors report that stool frequency, fecal incontinence and abdominal pain significantly improved. However, due to incomplete reporting of the results, it is difficult to interpret these results.