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305 Outcomes of sacral nerve stimulation 15 after SNS replacement, the patient developed both worsened constipation and nocturnal enuresis and was found to have a malfunctioning lead. She underwent lead revision with subsequent symptomatic improvement. TABLE 1: Clinical symptoms and patient-reported outcomes at baseline and follow-up after SNS treatment. Outcome Baseline Follow-up P -value Clinical Symptoms, n (%) Defecation <3 times per week a 4/22 (18%) 3/22 (14%) 1.00 Fecal incontinence 18/25 (72%) 5/25 (20%) <.01 Urinary incontinence 14/25 (56%) 7/25 (28%) .04 Abdominal pain a 15/22 (68%) 9/22 (41%) .11 Patient-Reported Outcomes, median (IQR) GSS 59.7 (42.4-72.2) 80.6 (55.6-88.9) .01 FIQL: Lifestyle 3.0 (2.3-3.9) 3.9 (3.3-4.0) .01 FIQL: Coping/Behavior 2.8 (2.2-3.9) 3.7 (3.3-4.0) <.01 FIQL: Depression 2.8 (2.4-3.6) 3.3 (2.9-3.6) .08 FIQL: Embarrassment 3.0 (1.7-3.3) 3.3 (2.3-4.0) .01 FISI 32.5 (26.0-39.0) 30.0 (12.0-40.0) .01 a Baseline defecation frequency and abdominal pain was unavailable for three patients. GSS, PedsQL Gastrointestinal Symptom Scale; higher scores suggest improvement; FIQL, Fecal Incontinence Quality of Life Scale; higher scores suggest improvement; FISI, Fecal Incontinence Severity Index; lower scores suggest improvement. Shortly after the second stage procedure, one patient experienced lower extremity numbness and discomfort with sitting. This patient underwent repositioning of the SNS pulse generator within a month of the second stage procedure with subsequent resolution of the numbness and discomfort. One patient experienced a relapse of symptoms requiring further surgical intervention. After a brief period of improvement in constipation symptoms for the three months following SNS initiation, this patient's symptoms gradually returned over the following year despite SNS treatment. This patient subsequently underwent partial colectomy with colorectal anastomosis approximately 15 months after SNS placement. This patient continues to have an SNS in place but has had infrequent stools and regular fecal incontinence at follow-up.