14781-koppen

43 Prevalence of functional defecation disorders 1 TABLE 3. Pooled prevalence and association of study characteristics Functional constipation Functional nonretentive fecal incontinence Studies ( n ) Subjects ( n ) Pooled prevalence % (95% CI) Meta-regression P -value Studies ( n ) Subjects ( n ) Pooled prevalence % (95% CI) Meta-regression P -value Total 33 65147 9.5 (7.5-12.1) n/a 15 18107 0.4 (0.2-0.7) n/a Geographical location Asia 16 49148 6.3 (4.0-9.6) 6 12045 0.3 (0.2-0.4) Central and South America 12 10435 13.3 (11.2-15.8) 7 3455 0.5 (0.2-1.0) Europe and North America 4 4746 12.4 (8.7-17.3) .018* 2 2607 1.0 (0.3-3.4) .056 Age <4 years 2 6213 17.5 (10.7-27.1) 0 0 n/a ≥4 years 26 54237 9.6 (7.2-12.6) .223 15 18107 n/a n/a Quality score (max score 12) 9 or 10 14 20310 8.8 (6.1-12.5) 6 7564 0.4 (0.2-0.9) 11 17 39249 9.3 (4.9-17.0) 9 10543 0.3 (0.1-0.7) 12 2 5588 9.3 (4.9-17.0) .783 0 0 n/a .592 * statistically significant; n/a not applicable