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GENERAL INTRODUCTION AND OUTLINE OF THE THESIS Parts of this introduction have been published as: Childhood constipation: finally something is moving! Ilan J.N. Koppen, Carlo Di Lorenzo, Miguel Saps, Phil G. Dinning, Desale Yacob, Marc A. Levitt, Marc A. Benninga Expert Review of Gastroenterology & Hepatology 2016;10:141-55 & Chapter: Functional Constipation in Children Ilan J.N. Koppen, Marc A. Benninga In: Faure C., Thapar N., Di Lorenzo C. (eds) Pediatric Neurogastroenterology pp.445-458 (2017) Springer, New York.