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General introduction and outline of the thesis 9
Chapter 1 Prevalence of functional defecation disorders in children; a systematic review and meta-analysis 31
Chapter 2 Is there an association between functional constipation and excessive bodyweight in children? 61
Chapter 3 Functional defecation disorders and excessive body weight: a systematic review 73
Chapter 4 Attention deficit hyperactivity disorder and functional defecation disorders in children 97
Chapter 5 Using the Bristol Stool Scale and parental report of stool consistency as part of the Rome III criteria for functional constipation in infants and toddlers 115
Chapter 6 The Brussels Infant and Toddler Stool Scale ('BITSS'): a study on inter-rater reliability 129
Chapter 7 Characterizing colonic motility in children with chronic intractable constipation: a look beyond high-amplitude propagating sequences 149
Chapter 8 Impaired postprandial colonic response in the presence of coordinated propagating colonic contractions suggests an extrinsic neuropathy in children and adolescents with intractable functional constipation 175
Chapter 9 Segmental colonic dilation is associated with premature termination of high-amplitude propagating contractions in children with intractable functional constipation 193
Chapter 10 Awareness and implementation of the 2014 ESPGHAN/ NASPGHAN guideline for childhood functional constipation 213
Chapter 11 Adherence to polyethylene glycol treatment in children with functional constipation is associated with parental illness perceptions, satisfaction with treatment and perceived treatment convenience 227
Chapter 12 Is there a role for pre-, pro- and synbiotics in the treatment of functional constipation in children? A systematic review 247
Chapter 13 Transanal irrigation in the treatment of children with intractable functional constipation 265
Chapter 14 Surgical decision-making in the management of children with intractable functional constipation: what are we doing and are we doing it right? 279
Chapter 15 Sacral nerve stimulation for constipation and fecal incontinence in children: long-term outcomes, patient benefit, and parent satisfaction 299
Chapter 16 Surgical management of children with intractable functional constipation; experience of a single tertiary children's hospital 315
Summary and discussion 335
Nederlandse samenvatting en discussie 347
Appendices Contributing authors 359
List of publications 363
PhD portfolio 369
Dankwoord 373
About the author 379

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