Bibian van der Voorn

111 GR/MR VARIATION ON IQ & BEHAVIOR AFTER PREMATURITY reasoning and spatial visualization and a trend (p=0.06) towards a higher Z-score for mathematical capacity. Carriage of the R23K SNP was not related to self-reported behavior scores. Carriage of the R23K SNP was associated with a decrease in parent- reported attention problems and a trend (p= 0.06) towards a decrease in parent- reported total sum score for problem behavior. Interaction between the R23K SNP and antenatal glucocorticoid treatment (n=8) was observed, with a decrease of -4.1 points (95% CI -7.7 to -0.4 [p=0.03]) in parent-reported other problems and a trend towards a decrease in parent-reported total sum score for problem behavior (-16.3 [95% CI -34.5 to 1.9] p=0.08). TABLE 1. Baseline characteristics Antenatal glucocorticoid treatment (n=71) No treatment (n=273) P-value Gestational age (wks) 29.5 ± 1.5 29.9 ± 1.5 0.07 Birth weight (g) 1311 ± 322 1332 ± 340 0.62 Birth weight (sds) -0.1 ± 0.8 -0.2 ± 1.0 0. 40 SGA < -1 SD 8 (11%) 50 (18%) 0.16 Male 42 (59%) 132 (48%) 0.11 Postnatal glucocorticoid treatment 3 (4%) 27 (10%) 0.13 Necrotizing enterocolitis 2 (3%) 19 (7%) 0.19 Apgar score <7 5 minutes postpartum 5 (7%) 35 (13%) 0.14 Neonatal convulsions 1 (1%) 10 (4%) 0.34 Low socioeconomic status 25 (35%) 98 (36%) 0.91 GR genotype R23K carrier 8 (11%) 19 (7%) 0.24 N363S carrier 4 (6%) 13 (5%) 0.75 MR genotype -2G/C CC genotype 16 (22%) 52 (20%) 0.59 -2G/C GG genotype 17 (24%) 61 (23%) 0.87 I180V carrier 11 (16%) 51 (19%) 0.40 Continuous variables are presented as mean ± SD and compared with an independent t-test. Dichotomous variables are presented as N (percentages) and compared with a Chi-Square test. Data are shown for subjects who received antenatal glucocorticoid treatment and subjects who did not. TABLE 2. Genetic characteristics GR genotype MR genotype R23K Carrier (N=27) N363S Carrier (N=17) -2G/C CC genotype (N=68) -2G/C GG genotype (N=78) I180V Carrier (N=62) GR genotype R23K carrier - 0 6 8 4 N363S carrier 0 - 2 7 2 MR genotype -2G/C CC genotype 6 2 - - 24 -2G/C GG genotype 8 7 - - 0 I180V carrier 4 2 24 0 - Dichotomous variables are presented as N