Bibian van der Voorn

112 CHAPTER 8 TABLE 3. Relation between antenatal glucocorticoid treatment versus IQ, YASR and YABCL scores. IQ IQ-score -1.2 (-5.3 to 2.8) Linguistic capacity Z-score -0.1 (-0.3 to 0.1) Mathematical capacity Z-score -0.1 (-0.4 to 0.1) Logical reasoning Z-score -0.1 (-0.4 to 0.1) Spatial visualization Z-score -0.1 (-0.4 to 0.1) YASR Internalizing sum score 2.4 (0.3 to 4.5) * Externalizing sum score 0.7 (-0.8 to 2.1) Total sum score 5.2 (-0.8 to 11.2) Anxious/depressed 1.8 (0.2 to 3.4) * Withdrawn 0.6 (-0.04 to 1.3) Somatic complaints 0.6 (-0.3 to 1.5) Aggressive behavior 0.5 (-0.2 to 1.3) Delinquent behavior 0.1 (-0.4 to 0.5) Thought problems 0.2 (0.0 to 0.5) * Attention problems 0.2 (-0.4 to 0.8) Intrusive behavior 0.1 (-0.5 to 0.6) Other problems 1.0 (-1.0 to 3.0) YABCL Internalizing sum score 3.9 (2.2 to 5.7) * Externalizing sum score 3.2 (1.3 to 5.1) * Total sum score 13.3 (7.5 to 19.2) * Anxious/depressed 2.9 (1.5 to 4.2) * Withdrawn 1.1 (0.6 to 1.6) * Aggressive behavior 2.0 (0.8 to 3.3) * Delinquent behavior 0.8 (0.4 to 1.2) * Somatic complaints 0.8 (0.1 to 1.4) * Thought problems 0.8 (0.4 to 1.2) * Attention problems 1.9 (0.7 to 3.0) * Intrusive behavior 0.4 (-0.2 to 0.9) Other problems 2.8 (1.6 to 4.0) * IQ, intellectual subdomain,YASR andYABCL scores are presented as regression coefficient (95% CI) and are corrected for sex. * p<0.05 Carriage of the N363S SNP was not related to IQ score or the intellectual subdomains, except for linguistic capacity, which tended to be higher (p=0.06). Carriage of the N363S SNP was not related to self-reported or parent-reported behavior. Interaction between the N363S SNP and antenatal glucocorticoid treatment (n=4) was observed, with a decrease in the intellectual subdomains linguistic capacity of -1.2 SD (95% CI -2.3 to -0.1 [p=0.04]) and logical reasoning of -1.4 SD (95% CI -2.5 to -0.4 [p=0.01]), as well as a trend towards a decrease in IQ-score (-16.4 [95% CI -34.0 to 1.2] p=0.07). Table 5 shows the relation between the MR polymorphisms versus IQ, YASR and YABCL scores. The -2G/C GG-genotype was not related to IQ, YASR or YABCL scores, except for parent-reported intrusive behavior and other problems. The -2G/C CC- genotype was associated with a decrease in IQ-score, as well as with decreases in all intellectual subdomains, except for spatial visualization. The -2G/C CC-genotype was not related to YASR or YABCL scores. Interaction between -2G/C variation and antenatal glucocorticoid treatment (n=33) was observed and was associated with a