Bibian van der Voorn

113 GR/MR VARIATION ON IQ & BEHAVIOR AFTER PREMATURITY decrease of -0.7 SD (95% CI -1.2 to -0.1 [p=0.02]) in spatial visualization in exposed carriers of the GG-genotype, as well as a decrease of -0.7 points (95% CI -1.3 to -0.1 [p=0.02]) for self-reported thought problems and an increase of 4.2 points (95% CI 1.0 to 7.4 [p=0.01] ) for parent-reported aggressive behavior in exposed carriers of the CC-genotype. TABLE 4. Relation between GR polymorphisms versus IQ, YASR and YABCL scores. R23K SNP N363S SNP IQ IQ-score 9.3 (3.4 to 15.1) * 5.8 (-1.9 to 13.4) Linguistic capacity Z-score 0.2 (-0.1 to 0.5) 0.4 (-0.01 to 0.8) Mathematical capacity Z-score 0.4 (-0.01 to 0.8) 0.1 (-0.4 to 0.6) Logical reasoning Z-score 0.4 (0.1 to 0.7) * 0.2 (-0.2 to 0.7) Spatial visualization Z-score 0.5 (0.2 to 0.8) * 0.3 (-0.2 to 0.7) YASR Internalizing sum score -1.5 (-4.6 to 1.7) 0.7 (-3.2 to 4.5) Externalizing sum score -1.8 (-4.0 to 0.3) -0.6 (-3.2 to 2.0) Total sum score -5.2 (-13.9 to 3.5) 0.4 (-10.1 to 10.9) Anxious/depressed -1.4 (-3.8 to 1.1) -0.1 (-3.2 to 2.6) Withdrawn -0.1 (-1.1 to 0.9) 1.0 (-0.2 to 2.2) Aggressive behavior -0.8 (-1.9 to 0.4) -0.3 (-1.7 to 1.2) Delinquent behavior -0.5 (-1.1 to 0.2) -0.3 (-1.1 to 0.4) Somatic complaints -0.1 (-1.5 to 1.2) 0.4 (-1.2 to 2.0) Thought problems -0.1 (-0.5 to 0.2) -0.1 (-0.5 to 0.3) Attention problems -0.7 (-1.6 to 0.2) 0.6 (-0.5 to 1.6) Intrusive behavior -0.6 (-1.4 to 0.3) -0.02 (-1.0 to 1.0) Other problems -1.4 (-4.3 to 1.6) -0.8 (-4.3 to 2.8) YABCL Internalizing sum score -1.7 (-4.3 to 0.9) -0.04 (-3.2 to 3.2) Externalizing sum score -2.3 (-5.1 to 0.5) -0.4 (-3.8 to 3.1) Total sum score -8.5 (-17.3 to 0.2) -0.7 (-11.5 to 10.1) Anxious/depressed -1.4 (-3.5 to 0.6) -0.5 (-3.0 to 2.0) Withdrawn -0.3 (-1.0 to 0.5) 0.5 (-0.4 to 1.4) Aggressive behavior -1.5 (-3.3 to 0.3) 0.5 (-1.8 to 2.7) Delinquent behavior -0.3 (-0.9 to 0.4) -0.3 (-1.1 to 0.4) Somatic complaints -0.2 (-1.1 to 0.8) 0.3 (-0.9 to 1.4) Thought problems -0.4 (-1.0 to 0.2) -0.1 (-0.9 to 0.6) Attention problems -2.5 (-4.2 to -0.8) * 0.1 (-2.0 to 2.2) Intrusive behavior -0.5 (-1.4 to 0.3) -0.5 (-1.5 to 0.5) Other problems -1.6 (-3.4 to 0.2) -0.6 (-2.8 to 1.6) IQ, intellectual subdomain,YASR andYABCL scores are presented as regression coefficient (95% CI) and are corrected for sex. SNP carriers are compared with non-carriers. * p<0.05 Carriage of the MR I180V SNP was not related with IQ-score or the intellectual subdomains, but it was associated with a decrease in self-reported and parent- reported anxious/depressed behavior, a decrease in parent-reported internalizing behavior and a trend (p=0.06) towards a decrease in self-reported internalizing behavior. Interaction between the I180V SNP and antenatal glucocorticoid treatment (n=11) was observed, with a decrease in logical reasoning of -0.6 SD (95%CI -1.2 to -0.02 [p=0.04]) and a trend towards a decrease in linguistic capacity of -0.5 SD