Marieke van Rosmalen

Prognostic value of quantitative MRI in chronic inflammatory neuropathies 117 7 Table 7.3 Mean differences of MRI parameters between the first and second research MRI Parameter Nerve root CIDP (n = 23) MMN (n = 7) FA Mean dif 95% CI p Mean dif 95% CI p All -0.005 -0.019 – 0.010 0.544 -0.019 -0.068 – 0.029 0.368 C5 -0.003 -0.024 – 0.019 0.788 -0.045 -0.139 – 0.048 0.280 C6 -0.002 -0.021 – 0.018 0.863 -0.015 -0.071 – 0.042 0.550 C7 -0.010 -0.032 – 0.011 0.318 0.002 -0.030 – 0.034 0.907 MD (x 10 -3 mm 2 /s) All -0.054 -0.095 – -0.014 0.012 -0.064 -0.168 – 0.040 0.184 C5 -0.080 -0.155 – -0.004 0.040 -0.123 -0.378 – 0.133 0.285 C6 -0.010 -0.056 – 0.037 0.666 -0.001 -0.173 – 0.172 0.991 C7 -0.078 -0.164 – 0.009 0.076 -0.068 -0.131 – -0.005 0.037 AD (x 10 -3 mm 2 /s) All -0.072 -0.129 – -0.014 0.018 -0.098 -0.199 – 0.003 0.057 C5 -0.100 -0.205 – 0.005 0.063 -0.206 -0.550 – 0.139 0.195 C6 -0.015 -0.084 – 0.055 0.669 -0.003 -0.180 – 0.174 0.968 C7 -0.108 -0.213 – 0.004 0.042 -0.085 -0.163 – -0.007 0.035 RD (x 10 -3 mm 2 /s) All -0.045 -0.081 – -0.010 0.015 -0.047 -0.150 – 0.056 0.310 C5 -0.069 -0.132 – -0.006 0.034 -0.081 -0.300 – 0.138 0.400 C6 -0.007 -0.047 – 0.032 0.705 0.000 -0.172 – 0.173 0.998 C7 -0.064 -0.141 – 0.018 0.123 -0.059 -0.128 – 0.009 0.083 T2 relaxation time (ms) All -0.379 -0.212 – 1.172 0.552 -1.398 -6.789 – 4.235 0.591 C5 -0.781 -2.697 – 1.140 0.407 1.327 -5.404 – 9.539 0.522 C6 -0.280 -2.535 – 1.975 0.798 -2.012 -8.992 – 4.969 0.507 C7 -0.057 -2.423 – 2.154 0.903 -3.315 -8.106 – 1.475 0.141 Fat fraction (%) All 2.307 0.050 – 4.463 0.045 3.184 -1.854 – 8.218 0.174 C5 2.412 0.166 – 4.657 0.036 5.068 -4.108 – 14.412 0.223 C6 2.777 -0.510 – 6.063 0.093 1.180 -3.868 – 6.227 0.622 C7 1.647 -1.606 – 4.893 0.299 3.440 -4.074 – 10.954 0.341 Mean differences of diffusion parameters, T2 relaxation time and fat fraction between research MRI 1 and research MRI 2, with 95% confidence intervals and p values, visualized for patients with CIDP and MMN separately. Abbreviations: CIDP = chronic inflammatory demyelinating polyneuropathy; MMN = multifocal motor neuropathy; Mean dif = mean difference; CI = confidence interval; FA = fractional anisotropy; MD = mean diffusivity; AD = axial diffusivity; RD = radial diffusivity; ms = milliseconds.