Marieke van Rosmalen

Chapter 2 30 was significantly higher for patients diagnosed before 2007 ( p < 0.01), probably due to a different treatment regime with repeated loading doses of immunoglobulins in the period before 1995 rather than lower-dosed weekly to monthly maintenance therapy. We found no significant differences in clinical characteristics between males and females. Figure 2.1 Flowchart of study MMN cohort in 2015 n = 152 Not reached n = 9 Deceased n = 8 No time/interest n = 11 Nationwide cohort study 2007 n = 88 Not reached n = 3 Missing data n = 1 No time/interest n = 10 "new" MMN patients n = 54 Follow-up study n = 60 Follow-up study n = 40 Cross-sectional cohort study n = 100 Abbreviations: MMN = multifocal motor neuropathy. Weakness, sensory function and tendon reflexes The distribution of muscle weakness was distal more than proximal and more pronounced in hand than in foot or lower leg muscles ( Supplemental table 2.2 ). Finger flexion and plantar foot flexion were relatively spared compared to hand and finger extension and dorsal foot flexion. Patients with longer disease duration had significantly more weakness in hand and lower leg or foot muscles