Diagnostic value of quantitative assessment of brachial plexus MRI in chronic inflammatory neuropathies 63 4 Table 4.4 Mean nerve root sizes per measurement site Nerve root Inflammatory neuropathy (n = 81) Control (n = 42) MD (95% CI) Level of significance CORONAL C5 Ganglion 3.0 (0.8) 2.5 (0.6) 0.5 (0.3 – 0.7) < 0.001 1 cm 2.8 (0.9) 2.2 (0.5) 0.6 (0.3 – 0.8) < 0.001 C6 Ganglion 3.8 (0.9) 3.3 (0.6) 0.5 (0.2 – 0.8) < 0.001 1 cm 3.6 (1.1) 2.9 (0.7) 0.7 (0.3 – 1.1) < 0.001 C7 Ganglion 4.0 (0.9) 3.4 (0.7) 0.7 (0.3 – 1.0) < 0.001 1 cm 3.7 (1.1) 2.8 (0.6) 0.9 (0.4 – 1.4) < 0.001 SAGITTAL C5 Ganglion 21.6 (6.8) 18.5 (5.7) 3.1 (0.7 – 5.6) 0.013 1 cm 20.3 (7.2) 16.7 (4.4) 3.6 (1.1 – 6.1) 0.005 C6 Ganglion 27.2 (9.1) 23.4 (5.2) 3.8 (0.8 – 6.8) 0.013 1 cm 25.3 (11.5) 19.2 (6.5) 6.1 (2.0 – 10.2) 0.004 C7 Ganglion 26.4 (10.4) 22.0 (5.4) 4.4 (1.5 – 7.2) 0.003 1 cm 23.1 (14.7) 16.1 (4.3) 7.1 (0.9 – 13.3) 0.026 Nerve root sizes are mean (standard deviation). Coronal measurements are in millimetres (mm). Sagittal measurements are square millimetres (mm2) Abbreviations: MD = mean difference; CI = confidence interval; SD = standard deviation. ROC analysis and development of risk chart Sagittal measurements were less often successful because of lower data quality and overall lower reliability (Table 4.2 and 4.3). We therefore decided to exclude the measurements in the sagittal plane from further analysis. Results from the ROC analysis are shown in Figure 4.2. We found a comparable AUC for both predetermined anatomical sites in the coronal plane (G0 and G1). We developed a risk chart (Figure 4.3) that predicts the absolute chance of having a chronic inflammatory neuropathy, based on different combinations of nerve root sizes of C5, C6 and C7.
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