Marieke van Rosmalen

Chapter 6 92 ABSTRACT Objective: The immunological pathophysiologies of chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) differ considerably, but neither has been elucidated completely. Quantitative magnetic resonance imaging (MRI) techniques as diffusion tensor imaging, T2 mapping, and fat fraction analysis may indicate in vivo pathophysiological changes in nerve architecture. Our study aims to systematically study nerve architecture of the brachial plexus in patients with CIDP, MMN, motor neuron disease (MND) and healthy controls using these quantitative MRI techniques. Methods: We enrolled patients with CIDP (n = 47), MMN (n = 29), MND (n = 40) and healthy controls (n = 10). All patients underwent MRI of the brachial plexus and we obtained diffusion parameters, T2 relaxation times and fat fraction using an automated processing pipeline. We compared these parameters between groups using a univariate general linear model. Results: Fractional anisotropy was lower in patients with CIDP compared to healthy controls ( p < 0.001), patients with MND ( p = 0.010) and MMN ( p < 0.001). Radial diffusivity was higher in patients with CIDP compared to healthy controls ( p = 0.015) and patients with MND ( p = 0.001) and MMN ( p < 0.001). T2 relaxation time was elevated in patients with CIDP compared to patients with MND ( p = 0.023). Fat fraction was lower in patients with CIDP and MMN compared to patients with MND (both p < 0.001). Conclusion: Our results show that quantitative MRI parameters differ between CIDP, MMN and MND, which may reflect differences in underlying pathophysiological mechanisms.