Daan Pieren

114 Chapter 4 21. van den Berg, S. P. H. et al. Negative Effect of Age, but Not of Latent Cytomegalovirus Infection on the Antibody Response to a Novel Influenza Vaccine Strain in Healthy Adults . Front. Immunol. 9, 82, doi:10.3389/fimmu.2018.00082 (2018). 22. Tcherniaeva, I. et al. The development of a bead-based multiplex immunoassay for the detection of IgG antibodies to CMV and EBV . J. Immunol. Methods 462, 1-8, doi:10.1016/j. jim.2018.07.003 (2018). 23. Amir el, A. D. et al. viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia . Nat. Biotechnol. 31, 545-552, doi:10.1038/ nbt.2594 (2013). 24. Suzuki, J. et al. The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation . Nat Commun 9, 3296, doi:10.1038/ s41467-018-05854-6 (2018). 25. Henson, S. M. et al. p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8(+) T cells . J. Clin. Invest. 124, 4004-4016, doi:10.1172/JCI75051 (2014). 26. Henson, S. M. et al. Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8(+) T-cell proliferation by distinct pathways . Eur. J. Immunol. 45, 1441-1451, doi:10.1002/eji.201445312 (2015). 27. Henson, S. M. et al. Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade . Immunology 135, 355-363, doi:10.1111/j.1365- 2567.2011.03550.x (2012). 28. Khan, N. et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals . J. Immunol. 169, 1984-1992, doi:10.4049/ jimmunol.169.4.1984 (2002). 29. Weng, N. P. et al. CD28(-) T cells: their role in the age-associated decline of immune function . Trends Immunol. 30, 306-312, doi:10.1016/j.it.2009.03.013 (2009). 30. Guillerey, C. et al. TIGIT immune checkpoint blockade restores CD8(+) T-cell immunity against multiple myeloma . Blood 132, 1689-1694, doi:10.1182/blood-2018-01-825265 (2018). 31. Tarazona, R. et al. Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells . Mech. Ageing Dev. 121, 77-88, doi:10.1016/s0047-6374(00)00199-8 (2000). 32. Ng, T. P. et al. Markers of T-cell senescence and physical frailty: insights from Singapore Longitudinal Ageing Studies . NPJ Aging Mech Dis 1, 15005, doi:10.1038/npjamd.2015.5 (2015).

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