Daan Pieren

184 Chapter 6 45. Machicote, A. et al. Human CD8(+)HLA-DR(+) Regulatory T Cells, Similarly to Classical CD4(+)Foxp3(+) Cells, Suppress Immune Responses via PD-1/PD-L1 Axis . Front. Immunol. 9, 2788, doi:10.3389/fimmu.2018.02788 (2018). 46. Rifa’i, M. et al. Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis . J. Exp. Med. 200, 1123-1134, doi:10.1084/jem.20040395 (2004). 47. Joller, N. et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses . Immunity 40, 569-581, doi:10.1016/j. immuni.2014.02.012 (2014). 48. Kurtulus, S. et al. TIGIT predominantly regulates the immune response via regulatory T cells . J. Clin. Invest. 125, 4053-4062, doi:10.1172/JCI81187 (2015). 49. Song, Y. et al. T-cell Immunoglobulin and ITIM Domain Contributes to CD8(+) T-cell Immunosenescence . Aging Cell 17, doi:10.1111/acel.12716 (2018). 50. Lozano, E. et al. The TIGIT/CD226 axis regulates human T cell function . J. Immunol. 188, 3869-3875, doi:10.4049/jimmunol.1103627 (2012). 51. Yu, X. et al. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells . Nat. Immunol. 10, 48-57, doi:10.1038/ni.1674 (2009). 52. Johnston, R. J. et al. The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function . Cancer Cell 26, 923-937, doi:10.1016/j.ccell.2014.10.018 (2014). 53. Sosinowski, T. et al. CD8alpha+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function . J. Immunol. 190, 1936-1947, doi:10.4049/jimmunol.1203149 (2013). 54. Kim, H. J. et al. Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance . Nature 467, 328-332, doi:10.1038/nature09370 (2010). 55. Busse, D. et al. Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments . Proc. Natl. Acad. Sci. U. S. A. 107, 3058-3063, doi:10.1073/pnas.0812851107 (2010). 56. Nakamura, R. et al. Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury . J. Virol. 84, 5574-5582, doi:10.1128/JVI.02030-09 (2010). 57. Gondek, D. C. et al. Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism . J. Immunol. 174, 1783-1786, doi:10.4049/jimmunol.174.4.1783 (2005). 58. Grossman, W. J. et al. Human T regulatory cells can use the perforin pathway to cause autologous target cell death . Immunity 21, 589-601, doi:10.1016/j.immuni.2004.09.002 (2004). 59. Fellows, E. et al. Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program . Blood 110, 544-552, doi:10.1182/blood-2006- 10-051649 (2007). 60. Betts, M. R. et al. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation . J. Immunol. Methods 281, 65-78, doi:10.1016/ s0022-1759(03)00265-5 (2003). 61. Peters, P. J. et al. Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes . J. Exp. Med. 173, 1099-1109, doi:10.1084/jem.173.5.1099 (1991). 62. Sheppard, S. et al. The Murine Natural Cytotoxic Receptor NKp46/NCR1 Controls TRAIL Protein Expression in NK Cells and ILC1s . Cell Rep 22, 3385-3392, doi:10.1016/j. celrep.2018.03.023 (2018). 63. Walczak, H. et al. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL . EMBO J. 16, 5386-5397, doi:10.1093/emboj/16.17.5386 (1997). 64. Ren, X. et al. Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4(+)CD25(+) regulatory T cells . Cell Death Differ. 14, 2076-2084, doi:10.1038/ sj.cdd.4402220 (2007). 65. Kim, H. J. et al. CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice . Proc. Natl. Acad. Sci. U. S. A. 108, 2010-2015, doi:10.1073/pnas.1018974108 (2011). 66. Parham, P. MHC class I molecules and KIRs in human history, health and survival . Nat. Rev. Immunol. 5, 201-214, doi:10.1038/nri1570 (2005).