Daan Pieren

186 Chapter 6 90. Laberge, R. M. et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation . Nat. Cell Biol. 17, 1049-1061, doi:10.1038/ncb3195 (2015). 91. Elyahu, Y. et al. Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes . Sci Adv 5, eaaw8330, doi:10.1126/sciadv. aaw8330 (2019). 92. Ferrer, I. R. et al. Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses . J. Immunol. 185, 2004-2008, doi:10.4049/ jimmunol.1001176 (2010). 93. Araki, K. et al. mTOR regulates memory CD8 T-cell differentiation . Nature 460, 108-112, doi:10.1038/nature08155 (2009). 94. Neff, F. et al. Rapamycin extends murine lifespan but has limited effects on aging . J. Clin. Invest. 123, 3272-3291, doi:10.1172/JCI67674 (2013). 95. Odorizzi, P. M. et al. Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells . J. Exp. Med. 212, 1125-1137, doi:10.1084/ jem.20142237 (2015). 96. McKinney, E. F. et al. T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection . Nature 523, 612-616, doi:10.1038/nature14468 (2015). 97. Schnell, A. et al. The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity . Cell Res. 30, 285-299, doi:10.1038/s41422-020-0277-x (2020). 98. Gustafson, C. E. et al. Influence of immune aging on vaccine responses . J. Allergy Clin. Immunol. 145, 1309-1321, doi:10.1016/j.jaci.2020.03.017 (2020). Figures presented in this chapter were created with BioRender.com