Daan Pieren

The work presented in this thesis was carried out within the Centre for Infectious Disease Control of the National Institute for Public Health and the Environment (RIVM) in collaboration with the division of Infectious Diseases and Immunology (Section Immunology) of the Utrecht University. QR-code: Scan to view the digital version of this thesis. ISBN: 978-94-6416-396-4 Cover design & Chapter illustrations: Daan Pieren Image: Arctic Ocean, stock photo ID: 518868286 Layout design: Vera van Ommeren | persoonlijkproefschrift.nl Printed by: Ridderprint | ridderprint.nl Copyright © 2021 Daan Pieren. All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without permission of the author. Printing of this thesis was financially supported by The National Institute for Public Health and the Environment (RIVM), the division of Infectious Diseases and Immunology (Section Immunology) of the Utrecht University, and the PhD program Infection & Immunity of the University Medical Center Utrecht.