Daan Pieren

27 General introduction and scope of this thesis 116. Furman, D. et al. Chronic inflammation in the etiology of disease across the life span . Nat. Med. 25, 1822-1832, doi:10.1038/s41591-019-0675-0 (2019). 117. Franceschi, C. et al. Inflamm-aging. An evolutionary perspective on immunosenescence . Ann. N. Y. Acad. Sci. 908, 244-254, doi:10.1111/j.1749-6632.2000.tb06651.x (2000). 118. Fulop, T. et al. Human Inflammaging . Gerontology 65, 495-504, doi:10.1159/000497375 (2019). 119. Morgan, O. W. et al. Morbid obesity as a risk factor for hospitalization and death due to 2009 pandemic influenza A(H1N1) disease . PLoS One 5, e9694, doi:10.1371/journal. pone.0009694 (2010). 120. Milner, J. J. et al. The impact of obesity on the immune response to infection . Proc. Nutr. Soc. 71, 298-306, doi:10.1017/S0029665112000158 (2012). 121. Kass, D. A. et al. Obesity could shift severe COVID-19 disease to younger ages . Lancet 395, 1544-1545, doi:10.1016/S0140-6736(20)31024-2 (2020). 122. Shen-Orr, S. S. et al. Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans . Cell Syst 3, 374-384 e374, doi:10.1016/j.cels.2016.09.009 (2016). 123. Chambers, E. S. et al. Can blocking inflammation enhance immunity during aging? J. Allergy Clin. Immunol. 145, 1323-1331, doi:10.1016/j.jaci.2020.03.016 (2020). 124. Bharath, L. P. et al. Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation . Cell Metab. 32, 44-55 e46, doi:10.1016/j.cmet.2020.04.015 (2020). 125. Desdin-Mico, G. et al. T cells with dysfunctional mitochondria induce multimorbidity and premature senescence . Science, doi:10.1126/science.aax0860 (2020). Figures presented in this chapter were created with BioRender.com 1