Daan Pieren

TABLE OF CONTENTS Chapter 1 General introduction and scope of this thesis 9 Chapter 2 Response kinetics reveal novel features of ageing in murine T cells Scientific Reports (2019) doi.org/10.1038/s41598-019-42120-1 29 Chapter 3 Compromised DNA repair promotes the accumulation of regulatory T cells with an aging-related phenotype and responsiveness Manuscript under review 63 Chapter 4 Co-expression of TIGIT and Helios refines the definition of immunosenescent CD8 + T cells during aging Manuscript in preparation 97 Chapter 5 Regulatory KIR + RA + CD8 + T cells accumulate with age and may aggravate viral respiratory disease in older adults Manuscript under review 119 Chapter 6 General discussion and future perspectives 161 Appendix Nederlandse samenvatting Curriculum vitae List of publications Dankwoord 189