Daan Pieren

87 Compromised DNA repair promotes the accumulation of regulatory T cells 48. Chaoul, N. et al. Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine- Induced Tumor Eradication . Cancer Res. 75, 3279-3291, doi:10.1158/0008-5472.CAN-15- 0454 (2015). 49. Battaglia, M. et al. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells . Blood 105, 4743-4748, doi:10.1182/blood-2004-10-3932 (2005). 50. Charbonnier, L. M. et al. Functional reprogramming of regulatory T cells in the absence of Foxp3 . Nat. Immunol., doi:10.1038/s41590-019-0442-x (2019). 51. Ferrer, I. R. et al. Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses . J. Immunol. 185, 2004-2008, doi:10.4049/ jimmunol.1001176 (2010). 52. Araki, K. et al. mTOR regulates memory CD8 T-cell differentiation . Nature 460, 108-112, doi:10.1038/nature08155 (2009). 53. Hoeijmakers, J. H. DNA damage, aging, and cancer . N. Engl. J. Med. 361, 1475-1485, doi:10.1056/NEJMra0804615 (2009). 3