Daan Pieren

Chapter 1 General introduction and scope of this thesis	9
Chapter 2 Response kinetics reveal novel features of ageing in murine T cells	29
Chapter 3 Compromised DNA repair promotes the accumulation of regulatory T cells with an aging-related phenotype and responsiveness	63
Chapter 4 Co-expression of TIGIT and Helios refines the definition of immunosenescent CD8+ T cells during aging	97
Chapter 5 Regulatory KIR+RA+ CD8+ T cells accumulate with age and may aggravate viral respiratory disease in older adults	119
Chapter 6 General discussion and future perspectives	161
Nederlandse samenvatting	190
Curriculum vitae	207
List of publications	209
Dankwoord	211

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