Maxime Verhoeven

125 Effectiveness and safety of treat-to-target strategies over 5 years Supplementary Figure S4 The course of TCZ dosages in each strategy over time, (n=226). TCZ+MTX= tocilizumab + methotrexate initiation strategy group; TCZ= tocilizumab + placebo-methotrexate initiation strategy group; MTX= methotrexate + placebo-tocilizumab initiation strategy group. Supplementary Figure S5 Any bDMARD use over 5 years, (n=226). TCZ+MTX= tocilizumab + methotrexate initiation strategy group; TCZ= tocilizumab + placebo-methotrexate initiation strategy group; MTX= methotrexate + placebo-tocilizumab initiation strategy group. Supplementary Figure S6 bDMARD use: Full or Reduced dose, (n=226). TCZ+MTX= tocilizumab + methotrexate initiation strategy group; TCZ= tocilizumab + placebo-methotrexate initiation strategy group; MTX= methotrexate + placebo-tocilizumab initiation strategy group. 6