Maxime Verhoeven

141 Cost-effectiveness of treat-to-target strategies over 5 years Table 3 Mean (2.5-97.5 percentile) difference in costs (€, rounded to the nearest hundreds) and QALYs, and ICER with distribution in cost effectiveness plane (%). Analysis Over 5 years TCZ+MTX vs. MTX TCZ vs. MTX base case Societal perspective # 35,600 (18,700 to 52,200) 5,000 (-10,500 to 20,800) QALYs 0.06 (-0.10 to 0.22) -0.03 (-0.20 to 0.13) ICER # 594,021 -149,241 % ( SE , SW, NW, NE) (0,0,23,77) (8,18,47,27) Sensitivity analyses complete case Societal perspective # 30,400 (9,100 to 51,200) 10,100 (-9,900 to 29,700) QALYs 0.01 (-0.14 to 0.16) -0.16 (-0.32 to 0.00) ICER # 3,586,015 -64,263 % ( SE , SW, NW, NE) (0,0,46,54) (0,16,81,3) QALY +0.05 intervention Societal perspective # 35,600 (18,700 to 52,200) 5,000 (-10,500 to 20,800) QALYs 0.12 (-0.04 to 0.28) 0.02 (-0.14 to 0.19) ICER # 296,907 194,208 % ( SE , SW, NW, NE) (0,0,7,93) (15,11,27,47) QALY -0.05 intervention Societal perspective # 35,600 (18,700 to 52,200) 5,000 (-10,500 to 20,800) QALYs 0.00 (-0.16 to 0.16) -0.09 (-0.25 to 0.07) ICER # -849,242,215 -53,908 % ( SE , SW, NW, NE) (0,0,50,50) (3,24,63,10) Discounting 4% for costs and QALYs Societal perspective # 35,600 (18,700 to 52,200) 5,000 (-10,500 to 20,800) QALYs 0.06 (-0.09 to 0.22) -0.03 (-0.18 to 0.13) ICER # 595,474 -186,561 % ( SE , SW, NW, NE) (0,0,22,78) (9,18,45,28) Scenario analyses TCZ-SC Societal perspective # 31,700 (14,900 to 48,000) -200 (-15,400 to 15,100) QALYs 0.06 (-0.10 to 0.22) -0.03 (-0.20 to 0.13) ICER # 528,655 4,539 % ( SE , SW, NW, NE) (0,0,23,77) (16,35,30,19) TCZ-SC -10% Societal perspective # 30,500 (13,700 to 46,800) -1,700 (-16,700 to 13,400) QALYs 0.06 (-0.10 to 0.22) -0.03 (-0.20 to 0.13) ICER # 508,807 51,233 % ( SE , SW, NW, NE) (0,0,23,77) (19,40,26,15 ) TCZ-SC -30% Societal perspective # 28,100 (11,400 to 44,500) -4,900 (-2,000 to 9,900) QALYs 0.06 (-0.10 to 0.22) -0.03 (-0.20 to 0.13) ICER # 468,847 145,244 % ( SE , SW, NW, NE) (0,0,23,77) (25,49,16,10) subgroup DAS28>5.1 Societal perspective # 34,400 (11,100 to 57,400) 1,400 (-21,100 to 23,600) QALYs 0.07 (-0.17 to 0.30) -0.01 (-0.25 to 0.24) ICER # 509,695 -257,000 % ( SE , SW, NW, NE) (0,0,29,71) (21,24,28,27) Outcomes based on single imputation nested in 10,000 bootstraps, costs expressed in euro’s. 7