Maxime Verhoeven

146 Chapter 7 10,000 bootstrap samples per treatment arm with complete data reflecting both sample uncertainty as well as the uncertainty due to data imputation. 1 = Brand J, van Buuren S, le Cessie S, van den Hout W. Combining multiple imputation and bootstrap in the analysis of cost-effectiveness trial data. Stat Methods Med Res. 2019;38:210–20. Supplementary Table 1 reference prices in €. Productivity costs Average gross wage per hour Amount - male 38.78 - female 32.33 Medication costs Variable Dose Costs Methotrexate 15 tablets of 2.5mg each 2.49 Tocilizumab 1 1.5 vial of 20mg/ml 614.15 Tocilizumab 1 syringe of 0.9ml injection fluid 297.50 Hydroxychloroquine 50 tablets of 200mg each 6.32 Adalimumab 1 syringe of 0.4 ml injection fluid 570.92 Etanercept 1 syringe of 1ml injection fluid 229.59 Leflunomide 30 tablets of 10mg each 33.97 Sulfasalazine 60 tablets of 500mg each 3.69 Rituximab 2 15 vials of 10mg/ml 3790.45 Glucocorticoids (prednisolone) 60 tablets of 2.5 mg each 16.33 Glucocorticoids 3 (methylprednisolone) 7.5 vials of 40mg/ml 16.84 NSAIDs 2 tablets of 220mg each 0.30 Day admission price 2009 (267€) * 1.10 = price 2014 price 2014 * 1.023 = price 2017 300.46 Day admission ≤1 hour price 2009 (82€) * 1.10 = price 2014 price 2014 * 1.023 = price 2017 92.27 co-medication rituximab - 1000 mg paracetamol (orally) - 2 mg tavegil (iv) - 100 mg methylprednisolone (Solu-Medrol) iv. 4.44 Direct healthcare costs Variable Frequency Costs General day admission per day 476 X-ray, echo per time 83.50 MRI-scan per time 222 CT-scan per time 142.5 general surgery per time 1300 Hospital day, academic center per day 643 Hospital day, general hospital per day 443