Maxime Verhoeven

148 Chapter 7 Supplementary Table 3 Cost (€, rounded to the nearest hundreds) and QALYs over time per initial treatment strategy in means (2.5-97.5 percentiles), using discounted values. TCZ+MTX (n=106) TCZ (n=103) MTX (n=108) Total medication costs - year 1 17,900 (17,000 to 18,800) 18,400 (17,500 to 19,200) 4,400 (3,500 to 5,300) - year 2 10,000 (8,800 to 11,300) 10,700 (9,500 to 12,000) 8,800 (7,400 to 10,100) - year 3 8,100 (7,100 to 9,100) 8,700 (7,700 to 9,700) 7,300 (6,200 to 8,300) - year 4 4,800 (4,200 to 5,400) 5,300 (4,700 to 5,900) 4,800 (4,000 to 5,600) - year 5 300 (200 to 500) 700 (300 to 1,100) 1,400 (800 to 2,100) - over 2 years 27,900 (26,100 to 29,800) 29,100 (27,200 to 30,900) 13,200 (11,100 to 15,200) - over 5 years 41,200 (37,800 to 44,600) 43,700 (40,400 to 47,200) 26,600 (22,500 to 30,700) TCZ costs - year 1 16,900 (15,800 to 18,000) 17,900 (17,000 to 18,800) 2,600 (1,900 to 3,400) - year 2 7,100 (5,700 to 8,500) 8,700 (7,300 to 10,100) 5,500 (4,200 to 6,900) - year 3 5,700 (4,600 to 6,900) 7,100 (6,000 to 8,200) 4,700 (3,600 to 5,800) - year 4 3,400 (2,700 to 4,000) 4,300 (3,600 to 5,000) 3,300 (2,500 to 4,000) - year 5 100 (0 to 300) 500 (200 to 900) 1,400 (800 to 2,000) - over 2 years 24,000 (21,700 to 26,300) 26,600 (24,500 to 28,800) 8,100 (6,200 to 10,100) - over 5 years 33,300 (29,300 to 37,200) 38,500 (34,600 to 42,500) 17,400 (13,500 to 21,500) Other bDMARD costs - year 1 900 (500 to 1,500) 400 (100 to 800) 1,600 (900 to 2,400) - year 2 2,900 (1,800 to 3,900) 1,900 (1,100 to 2,900) 3,200 (2,200 to 4,300) - year 3 2,300 (1,500 to 3,200) 1,600 (900 to 2,300) 2,600 (1,700 to 3,500) - year 4 1,400 (900 to 1,900) 1,000 (600 to 1,400) 1,500 (1,000 to 2,000) - year 5 200 (0 to 300) 200 (0 to 400) 0 (0 to 0) - over 2 years 3,800 (2,400 to 5,300) 2,300 (1,300 to 3,500) 4,800 (3,200 to 6,700) - over 5 years 7,700 (4,900 to 10,600) 5,100 (2,900 to 7,400) 8,900 (6,000 to 12,100) Other medication costs - year 1 100 (100 to 100) 100 (100 to 100) 100 (100 to 200) - year 2 0 (0 to 0) 0 (0 to 0) 100 (0 to 100) - year 3 0 (0 to 0) 0 (0 to 0) 100 (0 to 100) - year 4 0 (0 to 0) 0 (0 to 0) 0 (0 to 0) - year 5 0 (0 to 0) 0 (0 to 0) 0 (0 to 0) - over 2 years 100 (100 to 200) 100 (100 to 100) 200 (200 to 200) - over 5 years 200 (200 to 200) 200 (100 to 200) 300 (300 to 300) Total productivity loss costs # - year 1 6,700 (5,500 to 8,000) 5,600 (4,300 to 7,000) 6,500 (5,200 to 7,800) - year 2 19,300 (15,700 to 23,100) 14,700 (11,300 to 18,300) 17,100 (13,600 to 20,700) - year 3 15,600 (12,700 to 18,600) 11,900 (9,100 to 14,800) 13,800 (11, 000 to 16,800) - year 4 9,300 (7,500 to 11,100) 7,100 (5,500 to 8,900) 8,300 (6,600 to 10,100) - year 5 700 (300 to 1,100) 600 (100 to 1,200) 800 (400 to 1,300) - over 2 years 26,100 (21,300 to 31,000) 20,300 (15,700 to 25,100) 23,600 (18,900 to 28,400) - over 5 years 51,700 (42,100 to 61,600) 39,900 (30,800 to 49,600) 46,500 (37,100 to 56,200)