Maxime Verhoeven

150 Chapter 7 Supplementary Table 4 Cost (€, rounded to the nearest hundreds) and QALYs over time per initial treatment strategy in means (2.5-97.5 percentiles). TCZ+MTX (n=106) TCZ (n=103) MTX (n=108) Total medication costs - year 1 - year 2 - year 3 - year 4 - year 5 - over 5 years - over 2 years 17,900 (17,000 to 18,800) 10,400 (9,100 to 11,800) 8,800 (7,700 to 9,900) 5,400 (4,700 to 6,100) 400 (200 to 600) 42,900 (39,300 to 46,600) 28,300 (26,500 to 30,300) 18,400 (17,500 to 19,200) 11,100 (9,900 to 12,500) 9,400 (8,300 to 10,500) 6,000 (5,300 to 6,700) 800 (400 to 1,300) 45,700 (42,100 to 49,300) 29,500 (27,600 to 31,400) 4,400 (3,500 to 5,300) 9,100 (7,700 to 10,500) 7,900 (6,700 to 9,100) 5,400 (4,500 to 6,200) 1,600 (900 to 2,400) 28,400 (24,000 to 32,800) 13,500 (11,400 to 15,600) TCZ costs - year 1 - year 2 - year 3 - year 4 - year 5 - over 5 years - over 2 years 16,900 (15,800 to 18,000) 7,400 (6,000 to 8,900) 6,200 (5,000 to 7,400) 3,800 (3,100 to 4,500) 200 (100 to 300) 34,500 (30,300 to 38,700) 24,300 (22,000 to 26,600) 17,900 (17,000 to 18,800) 9,100 (7,600 to 10,500) 7,700 (6,500 to 8,900) 4,800 (4,100 to 5,600) 600 (200 to 1,000) 40,100 (35,9 to 44,300) 27,000 (24,8 to 29,200) 2,600 (1,900 to 3,400) 5,700 (4,300 to 7,200) 5,000 (3,900 to 6,300) 3,700 (2,800 to 4,500) 1,600 (900 to 2,400) 18,600 (14,400 to 23,000) 8,400 (6,400 to 10,400) Other bDMARD costs - year 1 - year 2 - year 3 - year 4 - year 5 - over 5 years - over 2 years 900 (500 to 1,500) 3,000 (1,900 to 4,100) 2,500 (1,600 to 3,500) 1,600 (1,000 to 2,200) 200 (100 to 400) 8,200 (5,300 to 11,300) 3,900 (2,5 00to 5,500) 400 (100 to 800) 2,000 (1,100 to 3,000) 1,700 (1,000 to 2,500) 1,100 (600 to 1,600) 200 (0 to 400) 5,400 (3,100 to 7,900) 2,400 (1,300 to 3,600) 1,600 (900 to 2,400) 3,300 (2,300 to 4,500) 2,800 (1,900 to 3,800) 1,700 (1,100 to 2,300) 0 (0 to 0) 9,400 (6,300 to 12,800) 5,000 (3,300 to 6,800) Other medication costs - year 1 - year 2 - year 3 - year 4 - year 5 - over 5 years - over 2 years 100 (100 to 100) 0 (0 to 100) 0 (0 to 0) 0 (0 to 0) 0 (0 to 0) 200 (200 to 200) 100 (100 to 200) 100 (100 to 100) 0 (0 to 0) 0 (0 to 0) 0 (0 to 0) 0 (0 to 0) 200 (200 to 200) 100 (100 to 100) 100 (100 to 200) 100 (100 to 100) 100 (0 to 100) 0 (0 to 0) 0 (0 to 0) 300 (300 to 400) 200 (200 to 200) Total productivity loss costs # - year 1 - year 2 - year 3 - year 4 - year 5 - over 5 years - over 2 years 6,700 (5,500 to 8,000) 20,100 (16,400 to 24,000) 16,900 (13,700 to 20,200) 10,500 (8,500 to 12,500) 800 (400 to 1,300) 55,000 (44,700 to 65,600) 26,800 (21,900 to 32,000) 5,600 (4,300 to 7,000) 15,300 (11,700 to 19,000) 12,900 (9,900 to 16,000) 8,000 (6,100 to 10,000) 700 (200 to 1,400) 42,500 (32,800 to 52,800) 20,900 (16,200 to 25,900) 6,500 (5,200 to 7,800) 17,800 (14,200 to 21,500) 15,000 (11,900 to 18,100) 9,300 (7,400 to 11,400) 900 (400 to 1,500) 49,500 (39,500 to 59,800) 24,200 (19,500 to 29,200)