Maxime Verhoeven

152 Chapter 7 Supplementary Table 5 Mean (2.5-97.5 percentile) difference in costs (€, rounded to the nearest hundreds) and QALYs, and ICER with distribution in cost effectiveness plane (%). TCZ+MTX vs. MTX TCZ vs. MTX Over 2 years Medication costs 14,800 (12,000 to 17,700) 16,000 (13,100 to 18,800) Direct healthcare costs 9,000 (4,300 to 14,000) -1,500 (-4,800 to 1,800) Indirect non-healthcare costs -600 (-1,700 to 0) 200 (-700 to 1,100) Productivity loss costs # 2,600 (-4,300 to 9,600) -3,300 (-10,200 to 3,500) Productivity loss costs $ 0 (-1,100 to 2,000) -300 (-1,900 to 1,200)   Total cost and effect Healthcare perspective 23,900 (18,300 to 29,600) 14,500 (9,900 to 19,000) Societal perspective # 25,900 (17,400 to 34,100) 11,400 (3,300 to 19,400) Societal perspective $ 23,700 (18,000 to 29,300) 14,400 (9,400 to 19,200) QALYs 0.05 (-0.02 to 0.12) 0.03 (-0.06 to 0.11) ICER HC % ( SE , SW, NW, NE) 432.048 (0,0,7,93) 552.199 (0,0,26,74) ICER # % ( SE , SW, NW, NE) 467.311 (0,0,7,93) 431.754 (0,0,26,74) ICER $ % ( SE , SW, NW, NE) 427.920 (0,0,7,93) 546.065 (0,0,26,74) Over 5 years Medication costs 14,500 (8,800 to 20,200) 17,300 (11,500 to 22,900) Direct healthcare costs 21,400 (10,400 to 32,400) -2,800 (-10,100 to 4,100) Indirect non-healthcare costs -4,600 (-6,100 to -3,200) -3,300 (-4,900 to -1,700) Productivity loss costs # 5,500 (-8,900 to 20,000) -7,000 (-21,200 to 7,200) Productivity loss costs $ 1,200 (-2,000 to 4,500) -200 (-3,500 to 3,100)   Total cost and effect Healthcare perspective 35,900 (22,700 to 48,800) 14,500 (4,400 to 24,200) Societal perspective # 36,800 (18,700 to 54,600) 4,200 (-12,500 to 20,900) Societal perspective $ 32,600 (19,800 to 45,500) 11,000 (600 to 21,100) QALYs 0.06 (-0.11 to 0.23) -0.04 (-0.21 to 0.14) ICER HC % ( SE , SW, NW, NE) 598,185 (0,0,24,76) -377,128 (0,0,67,33) ICER # % ( SE , SW, NW, NE) 613,487 (0,0,24,76) -108,609 (10,22,44,24) ICER $ % ( SE , SW, NW, NE) 542,200 (0,0,24,76) -287,097 (1,1,65,33) Outcomes based on single imputation nested in 10,000 bootstraps; costs expressed in euro’s. Undiscounted values. TCZ+MTX= initiation of tocilizumab + methotrexate strategy group; TCZ= initiation of tocilizumab + placebo- methotrexate strategy group; MTX= initiation of methotrexate + placebo-tocilizumab strategy group; Medication costs= all RA medication costs; Direct healthcare costs= all costs related to healthcare, also for other diseases (RA medication costs excluded); Indirect non healthcare costs= costs related to patient and family (e.g., travel cost, buying stair lift, etc.); Productivity loss costs= costs related to work loss or