Maxime Verhoeven

153 Cost-effectiveness of treat-to-target strategies over 5 years Supplementary Table 5 (continued) being less productive; # = using human capital approach; $ = using friction cost approach, only counting costs for a period of absence up to 85 days; Healthcare perspective= direct healthcare costs + medication costs; Societal perspective= direct healthcare costs + indirect not healthcare costs + productivity loss costs + medication costs; QALY= quality-adjusted life years; ICER= incremental cost effectiveness ratio (using societal perspective according to human capital approach); HC= healthcare perspective; SE = south east: gain in QALY, less expensive (i.e., TCZ dominant); SW= south west: loss in QALY, less expensive; NW= north west: loss in QALY, more expensive (i.e., TCZ inferior); NE= north east: gain in QALY, more expensive. Supplementary Table 6 Mean (2.5-97.5 percentile) difference in costs (€, rounded to the nearest hundreds) and QALYs with, and ICER with distribution in cost effectiveness plane (%). Analysis Over 5 years TCZ+MTX vs. MTX TCZ vs. MTX base case Societal perspective # 36,800 (18,700 to 54,600) 4,200 (-12,500 to 20,900) QALYs 0.06 (-0.11 to 0.23) -0.04 (-0.21 to 0.14) ICER # % ( SE , SW, NW, NE) 613,487 (0,0,24,76) -108,609 (10,22,44,24) Sensitivity analyses complete case Societal perspective # 31,000 (8,200 to 53,200) 9,400 (-11,900 to 30,400) QALYs 0.02 (-0.14 to 0.18) -0.14 (-0.30 to 0.02) ICER # % ( SE , SW, NW, NE) 2,127,794 (0,0,43,57) -62,967 (1,19,77,3) QALY +0.05 intervention Societal perspective # 36,800(18,700 to 54,600) 4,200 (-12,500 to 20,900) QALYs 0.12 (-0.05 to 0.29) 0.02 (-0.15 to 0.20) ICER # % ( SE , SW, NW, NE) 306,841 (0,0,8,92) 192,750 (17,15,26,42) QALY -0.05 intervention Societal perspective # 36,800 (18,700 to 54,600) 4,200 (-12,500 to 20,900) QALYs 0.00 (-0.17 to 0.17) -0.10 (-0.27 to 0.08) ICER # % ( SE , SW, NW, NE) 961,430,116 (0,0,50,50) -42,368 (3,28,59,10) Scenario analyses TCZ-SC Societal perspective # 32,900 (14,900 to 50,400) -1,100 (-17,300 to 15,200) QALYs 0.06 (-0.11 to 0.23) -0.04 (-0.21 to 0.14) ICER # % ( SE , SW, NW, NE) 548,356 (0,0,24,76) 29,373 (17,38,28,17) TCZ-SC -10% Societal perspective # 31,700 (13,700 to 49,200) -2,700 (-48,700 to 13,400) QALYs 0.06 (-0.11 to 0.23) -0.04 (-0.21 to 0.14) ICER # % ( SE , SW, NW, NE) 528,580 (0,0,24,76) 71,271 (20,43,23,14) 7