Maxime Verhoeven

194 Chapter 10 Table 4 Diagnostic values of DAS-OST formula in internal and external validation cohort. Validation cohort Disease activity state AU-ROC Sensitivity (95%CI) Specificity (95%CI) PPV (95%CI) NPV (95%CI) accuracy Internal DAS-OST Remission 0.93 0.84 (0.81 - 0.86) 0.86 (0.83 - 0.89) 0.89 (0.87 - 0.92) 0.79 (0.76 - 0.83) 0.85 Boolean 0.87 0.83 (0.78 - 0.88) 0.70 (0.67 - 0.73) 0.41 (0.36 - 0.45) 0.94 (0.93 - 0.96) 0.73 LDA 0.92 0.88 (0.86 - 0.90) 0.75 (0.70 - 0.80) 0.91 (0.89 - 0.93) 0.69 (0.64 - 0.74) 0.85 HDA 0.97 0.49 (0.33 - 0.65) 0.99 (0.99 - 1.00) 0.75 (0.58 - 0.92) 0.98 (0.97 - 0.99) 0.98 DAS-OST(JC) Remission 0.94 0.84 (0.82 - 0.87) 0.86 (0.83 - 0.89) 0.89 (0.87 - 0.92) 0.80 (0.76 - 0.83) 0.85 Boolean 0.86 0.75 (0.69 - 0.81) 0.77 (0.74 - 0.80) 0.45 (0.39 - 0.50) 0.93 (0.91 - 0.95) 0.77 LDA 0.92 0.88 (0.86 - 0.90) 0.74 (0.69 - 0.79) 0.91 (0.89 - 0.93) 0.69 (0.64 - 0.74) 0.85 HDA 0.97 0.49 (0.33 - 0.65) 1.00 (0.99 - 1.00) 0.78 (0.61 - 0.95) 0.98 (0.97 - 0.99) 0.98 DAS-OST without patient VAS Remission 0.82 0.83 (0.80 - 0.86) 0.65 (0.61 - 0.70) 0.77 (0.74 - 0.80) 0.73 (0.69 - 0.77) 0.75 Boolean 0.64 0.78 (0.72 - 0.83) 0.41 (0.38 - 0.45) 0.25 (0.21 - 0.28) 0.88 (0.85 - 0.91) 0.49 LDA 0.80 0.92 (0.91 - 0.94) 0.39 (0.33 - 0.45) 0.81 (0.79 - 0.84) 0.65 (0.58 - 0.72) 0.79 HDA 0.88 0.00 (0.00 - 0.00) 1.00 (1.00 - 1.00) n.a. 0.97 (0.96 - 0.98) 0.97