Maxime Verhoeven

213 DAS28 vs. DAS-OST; rheumatologist’s clinical classification Supplementary Table S1 Diagnostic values and agreement of clinical interpretation with (modified) disease activity outcomes. Disease activity state Diagnostic values Agreement Sensitivity Specificity PPV NPV Accuracy Cohen’s Kappa (95%CI) Gwet’s AC1 (95%CI) DAS28 # Remission 0.71 0.85 0.95 0.42 0.74 0.41 (0.37 – 0.46) 0.55 (0.51 – 0.60) LDA 0.87 0.72 0.93 0.58 0.84 0.54 (0.49 – 0.59) 0.76 (0.73 – 0.79) DAS-OST ## Remission 0.62 0.74 0.91 0.32 0.65 0.24 (0.20 – 0.29) 0.37 (0.32 – 0.42) LDA 0.81 0.59 0.89 0.44 0.77 0.36 (0.30 – 0.41) 0.64 (0.60 – 0.68) OST-score Optimal cut-off for inactive RA in males (OST-score ≤16.36) 0.66 0.50 0.85 0.26 0.63 0.11 (0.03 – 0.20) 0.37 (0.29 – 0.46) Optimal cut-off for inactive RA in females (OST-score ≤10.64) 0.53 0.63 0.85 0.25 0.55 0.10 (0.05 – 0.15) 0.17 (0.11 – 0.24) PPV= positive predictive value; NPV= negative predictive value; CI= confidence interval; DAS28= disease activity score assessing 28 joints; LDA= low disease activity; DAS-OST= disease activity using optical spectral transmission; OST-score= single measurement of optical spectral transmission. # Number of patients with; DAS28 remission and inactive= 858, DAS28 remission and active= 43, no DAS28 remission and inactive= 345, no DAS28 remission and active=252 DAS28 LDA and inactive= 1048, DAS28 LDA and active= 84, no DAS28 LDA and inactive= 155, no DAS28 LDA and active=211. ## Number of patients with; DAS-OST remission and inactive= 750, DAS-OST remission and active= 77, no DAS-OST remission and inactive= 453, no DAS-OST remission and active=218 DAS-OST LDA and inactive= 977, DAS-OST LDA and active= 120, no DAS-OST LDA and inactive= 226, no DAS-OST LDA and active=175. 11