Maxime Verhoeven

28 Chapter 2 Figure 1 Forest plot of DAS28 remission outcome in individual studies comparing remission-induction strategies with single csDMARD-initiating strategies. DAS28 remission= DAS28 <2.6; Induction= remission-induction strategy arm; csDMARD= single csDMARD- initiating strategy arm; M-H= Mantel-Haenszel; Random= random effect; CI= confidence interval; *= bDMARD in remission-induction strategy. Boolean-based remission For Boolean remission, 5/12 (42%) studies showed a statistically significant effect in favor of the remission-induction strategy. The pooled RR of achieving Boolean remission for the bDMARD based remission-induction strategy compared to the single csDMARD- initiating strategy without GC bridging was 1.75 [95%CI 1.40 - 2.20] versus 0.79 [95%CI 0.58 - 1.07] for the remission-induction strategy (1/5 bDMARD use in the remission- induction strategy) 29 compared to the single csDMARD-initiating strategy with GC bridging, Figure 2.