Maxime Verhoeven

30 Chapter 2 Figure 3 Forest plot of CDAI remission outcome in individual studies comparing re- mission-induction strategies with single csDMARD-initiating strategies. CDAI remission= CDAI ≤2.8; Induction= remission-induction strategy arm; csDMARD= single csDMARD- initiating strategy arm; M-H= Mantel-Haenszel; Random= random effect; CI= confidence interval. Figure 4 Forest plot of SDAI remission outcome in individual studies comparing re- mission-induction strategies with single csDMARD-initiating strategies. SDAI remission= SDAI ≤3.3; Induction= remission-induction strategy arm; csDMARD= single csDMARD- initiating strategy arm; M-H= Mantel-Haenszel; Random= random effect; CI= confidence interval; *= bDMARD based remission-induction strategy. Symptom duration Regarding symptom duration, 6 studies started treatment “within the window of opportunity” (symptom duration ≤3 months). Another 9 studies started treatment “outside the window of opportunity” (symptom duration >3 months; range 4 - 10 months). All studies reported the DAS28-based remission outcome, and 11/15 (73%) showed a statistical significant effect in favor of the remission-induction strategy. The