Maxime Verhoeven

55 An indirect comparison of treat-to-target strategies in early RA In Supplementary Table S2 the baseline characteristics are shown, for each trial, of the MTX strategy arms, which were used as reference in the analyses. DAS28, SJC28, TJC28, RF-positivity and alcohol use in these strategy arms were statistically significantly different between the 2 trials. This is in line with the comparison of the trial population overall (as also expected due to randomization within trials). Supplementary Table S2 Baseline characteristics for the MTX strategy arms, used as reference in the analyses. U-Act-Early MTX (ref) n= 108 CAMERA-II MTX (ref) N= 119 P-value Female, n (%) 69 (64) 72 (61) 0.68 Age (yrs.), mean (SD) 52.2 (13.7) 53.0 (13.0) 0.65 BMI (kg/m²), mean (SD) 26.2 (4.3) 25.9 (4.0) 0.54 Alcohol use (≥1 unit/week), n (%) 65 (60) 41 (39) <0.01 Current smoker, n (%) 31 (29) 31 (28) 1.00 Education level, n (%) Low Moderate High 48 (49) 37 (37) 14 (14) 41 (29) 27 (47) 22 (24) 0.36 Disease duration (days), median (IQR) 27.0 (15.0 – 46.0) * RF-positive status, n (%) 87 (81) 67 (68) 0.04 DAS28, mean (SD) 5.1 (1.2) 5.6 (1.2) <0.01 CRP (mg/L), median (IQR) 9.6 (3.0 – 23.0) 17.0 (8.0 – 41.5) 0.06 ESR (mm per h), median (IQR) 25 (12.0 – 46.0) 30.0 (15.0 – 48.0) 0.19 SJC28, median (IQR) 6.0 (3.0 – 10.0) 9.0 (6.0 – 15.0) <0.01 TJC28, median (IQR) 7.0 (4.0 – 10.0) 9.0 (5.0 – 13.0) 0.02 HAQ score, median (IQR) 1.0 (0.6 – 1.4) 1.3 (0.8 – 1.6) 0.11 Any radiographic joint damage, n (%) 29 (27) 24 (20) 0.27 Outcomes are based on non-imputed data of the 2 trials. Reported baseline characteristics of CAMERA- II slightly differ from those of the original publication as we presented non-imputed data compared to imputed data in that publication. 6,12 * not collected in CAMERA-II, but at least <1 year according to the inclusion criteria. SD= standard deviation; BMI= body mass index, RF= rheumatoid factor; DAS28= disease activity score assessing 28 joints [range 0-9.4, higher is more activity]; CRP= C-reactive protein in milligram per litre; IQR= interquartile range; ESR= erythrocyte sedimentation rate in millimetre per hour; SJC28= 28 swollen joint count; TJC28= 28 tender joint count; HAQ= health assessment questionnaire [range 0-3, 3= worst function]; any radiographic joint damage= total Sharp van der Heijde score ≥1. 3