Maxime Verhoeven

Chapter 1: General introduction	9
Chapter 2: Effectiveness of remission-induction strategies for early rheumatoid arthritis: a systematic literature review	19
Chapter 3: Initiating tocilizumab, with or without methotrexate, compared with starting methotrexate with prednisone within step-up treatment strategies in early rheumatoid arthritis: an indirect comparison of effectiveness and safety of the U-Act-Early and CAMERA-II treat-to-target trials	41
Chapter 4: Validation of a prognostic multivariable prediction model for insufficient clinical response to methotrexate in early rheumatoid arthritis and its clinical application in Evidencio	59
Chapter 5: Is tocilizumab monotherapy as effective in preventing radiographic progression in rheumatoid arthritis as its combination with methotrexate?	79
Chapter 6: Effectiveness and safety over 3 years after the 2-year U-Act-Early trial of the strategies initiating tocilizumab and/or methotrexate	103
Chapter 7: Effect on costs and quality-adjusted life-years of treat-to-target treatment strategies initiating methotrexate, or tocilizumab, or their combination in early rheumatoid arthritis	129
Chapter 8: Unravelling the cost of biological strategies in rheumatoid arthritis: a kaleidoscope of methodologies, interpretations and interests	159
Chapter 9: Utility of the HandScan in monitoring disease activity and prediction of clinical response in rheumatoid arthritis patients: an explorative study	169
Chapter 10: Development and validation of rheumatoid arthritis disease activity indices including HandScan (optical spectral transmission) scores	185
Chapter 11: Classification of RA into active or inactive disease, using a modified DAS with a HandScan score replacing joint counts	203
Chapter 12: A gender difference in HandScan scores in rheumatoid arthritis patients and controls?	215
Chapter 13: Summary and general discussion	221
Nederlandse samenvatting	234
Dankwoord	242
Curriculum vitae	245
List of publications	246
List of conference abstracts	248

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