Mylène Jansen

124 Chapter 6 considered predictive of the long-term outcome in regular care. Nevertheless, longer follow- up in regular care with larger number of patients is still warranted to proof this assumption. Moreover, such studies may benefit from standardized radiographs or MRI evaluation to evaluate joint tissue repair as well. Follow-up of more patients in regular care with proper data management may potentially provide treatment efficacy predictors, refining patient selection. Regardless, KJD as a regular care treatment results in significant clinical benefit 1 year post-treatment similar to that demonstrated in the clinical trials that have demonstrated sustainability of this initial effect. As such KJD, can be a joint-preserving of choice in relatively young patients with end stage knee OA.