Mylène Jansen

General introduction 13 1 different imaging techniques used are evaluated, reporting on the performance of the radiograph analysis technique KIDA for severe OA in chapter 11 , and comparing the characteristics of radiographs, MRI and CT in chapter 12 . Cartilage thickness changes are evaluated with MRI, and they are reported over the long-term after KJD treatment in chapter 13 , and are compared between KJD and HTO 2 years after treatment in chapter 14 . Further, cartilage quality represented by collagen structure after both treatments is evaluated using T2-mapping MRI in chapter 15 . In chapter 16 , synovial fluid marker changes during and after KJD and their association with clinical outcome are described. Bone changes are evaluated as well, as chapter 17 reports on osteophyte formation after KJD and HTO treatment. Furthermore, subchondral bone changes after KJD treatment are evaluated with CT, as described in chapter 18 . Finally, the results of these studies are summarized and discussed in an integrated way within a general perspective in chapter 19, the last chapter of this thesis.