Mylène Jansen

Systematic review and meta-analysis of KJD as treatment for OA 23 2 Results Study selection The selection process is shown in Figure 1. After duplicate exclusion from the initially found 495 articles, 239 titles and abstracts were screened and, after applying in- and exclusion criteria, 14 complete articles were screened. Of these, 3 were excluded, since they reported on a subgroup from other included articles without reporting extra information on primary outcomes, leaving 11 articles included for analysis. 12,13,22,14–21 Figure 1 : Flow diagram of article selection. As multiple articles reported on different follow-up moments in the same patient cohorts, the overview of selected studies is separated per cohort of KJD-treated patients and control groups (Table 1). 23 A total of 7 patient cohorts were treated with KJD, of which 2 in combination with another treatment: 1 cohort of 6 patients was treated with KJD and microfracture (Deie 2007) and 1 cohort of 19 patients treated with KJD, microfracture and debridement (Aly 2011) that also had a control group of 42 patients treated with microfracture and debridement alone. In an open prospective study 20 patients were treated with KJD, without control group, and follow-up was reported after 1 (Intema 2011), 2 (Wiegant 2013), 5 (Van der Woude 2017a),