Mylène Jansen

24 Chapter 2 and 9 (Jansen 2018) years. At 5 years follow-up, this cohort was compared on structural outcome measures with 138 untreated patients from the Osteoarthritis Initiative (OAI), who were matched on patient characteristics with the KJD patients. In a randomized controlled trial (RCT) 20 KJD patients were compared with 40 TKA patients after 1 (Van der Woude 2017b) and 2 (Jansen 2019a) years. In a different RCT 22 KJD patients were compared with 46 HTO patients after 1 (van der Woude 2017c) and 2 (Jansen 2019a) years. In regular care 40 patients were treated with KJD and evaluated after 1 year, without control group, reported in a conference abstract (Jansen 2019b). Lastly, a sub-group of 16 KJD patients and 17 HTO patients from the previously mentioned RCTs were evaluated and compared on an additional outcome measure (MRI cartilage thickness) after 2 years in a conference abstract (Jansen 2019c). Table 1 : Included studies Study Level of evidence 23 Treatment # patients Follow-up in years Reference(s) Outcome measures Knee joint distraction Case series: Distraction and microfracture IV KJD and microfracture 6 Average 3 (1.2–4.3) Deie et al. 2007 13 VAS pain, JSW Case series: Distraction, microfracture and debridement III-2 KJD, microfracture and debridement 19 Average 5 (4.8–6.8) Aly et al. 2011 14 JSW Open prospective study IV KJD 20 1, 2, 5, 9 Intema et al. 2011 15 ; Wiegant et al. 2013 16 ; Van der Woude et al. 2017a 17 ; Jansen et al. 2018 18 WOMAC, VAS pain, JSW, MRI RCT: KJD vs TKA II KJD 20 1, 2 Van der Woude et al. 2017b 19 ; Jansen et al. 2019a 20 WOMAC, VAS pain, KOOS, EQ-5D, JSW RCT: KJD vs HTO II KJD 22 1, 2 Van der Woude et al. 2017c 21 ; Jansen et al. 2019a 20 WOMAC, VAS pain, KOOS, EQ-5D, JSW Regular care (abstract) III-2 KJD 40 1 Jansen et al. 2019b 12 WOMAC RCT MRI sub-cohort (abstract) III-1 KJD 16 2 Jansen et al. 2019c 22 MRI