Mylène Jansen

Systematic review and meta-analysis of KJD as treatment for OA 27 2 Table 2 : Patient characteristics before treatment for patients treated with knee joint distraction in included studies 1 st author Age (year) Female:male ratio BMI (kg/m 2 ) Kellgren-Lawrence grade 1:2:3:4 Distraction duration (weeks) Deie 2011 13 51.7 (SD 7.8) 4:2 26.9 (SD 5.0) 0:0:1:5 9.3 (SD 2.1) Aly 2011 14 Range 39–65 15:4 4 Van der Woude 2017a 17 48.5 (SEM 1.3) 11:9 29.6 (SEM 0.8) 3:4:11:2 8 Van der Woude 2017b 19 54.9 (SEM 1.8) 11:9 27.4 (SEM 0.9) 0:1:8:11 6 Van der Woude 2017c 21 51.2 (SEM 1.1) 6:16 27.5 (SEM 0.7) 6:4:11:1 6.1 (range 5.6–7.1) Jansen 2019b 12 54.3 (SD 6.8) 17:23 27.7 (SD 3.9) 0:7:23:10 6.5 (SD 0.6) Jansen 2019c 22 Median 3 (IQR 1) Van der Woude 2017a is the open prospective study (also reported on by Intema 2011, Wiegant 2013, Jansen 2018); Van der Woude 2017b is the randomized controlled trial knee joint distraction versus total knee arthroplasty (also reported on by Jansen 2019a); Van der Woude 2017c is the randomized controlled trial knee joint distraction versus high tibial osteotomy (also reported on by Jansen 2019a). BMI: body mass index; IQR: interquartile range; SD: standard deviation; SEM: standard error of the mean. Outcome after knee joint distraction Primary outcome measures The results of the WOMAC, EQ-5D, and minimum JSW after KJD are summarized in Figures 3 – 5 respectively. The outcomes for the VAS pain, KOOS, mean JSW, and MRI cartilage thickness can be found in the supplementary data (Figures S1-S4). Patient cohorts treated with a combination of KJD and another therapy are not included in the figures. Neither are results from conference abstracts, as they did not report exact numbers. The WOMAC and VAS pain are evaluated in 3 cohorts after 1 year (patients n=62) and 2 years (n=59) and in 1 cohort after 5 years (n=20) and 9 years (n=8). The total WOMAC (Figure 3), VAS pain (Figure S1), and all WOMAC subscales were significantly increased compared to pre-treatment at all time points, with an MD varying between 21.2 (5 years, p= 0.001) and 29.9 (9 years, p< 0.001) for the WOMAC and between 27.6 (5 years, p< 0.001) and 46.6 (9 years; p< 0.001) for the VAS.