Mylène Jansen

30 Chapter 2 Other outcome measures Detailed results of additional outcome measures after KJD can be found in Table 3. In 2 cohorts after 1 (n=42) and 2 (n=39) years, the ICOAP (Intermittent and Constant Osteoarthritis Pain; scale 0 – 100, 0=best) and SF-36 (Short-Form 36; scale 0–100, 100=best) are reported. The ICOAP on 1 and 2 years and its subscales were significantly increased compared to pre-treatment, as was the SF-36 PCS (physical component scale). The MCS (mental component scale) was not different from pre-treatment values at 1 and 2 years. Knee flexion (degrees) was measured before and 1 year after KJD in 3 cohorts (n=62) and 2 years after KJD in 2 cohorts (n=40). After both 1 and 2 years there was no significant difference from baseline. The percentage subchondral bone without cartilage (denuded bone) is reported in 1 cohort (n=20) and was significantly lower (better) than baseline at 1 and 2 years but not at 5 years. The MRI RCT sub-cohort (n=16) graphically shows a significant decrease of this percentage of around 5. After KJD and microfracture (n=6) a significant increase in knee flexion and the Japanese Orthopaedic Association (JOA) score was reported. After KJD, microfracture and debridement (n=19) a significant increase in active knee flexion, pain, walking capacity, stair climbing and tibiofemoral angle was reported, but no difference in passive flexion. Table 3 : Changes in non-primary outcome parameters after knee joint distraction Knee joint distraction Δ1 year Δ2 years Δ5 years # cohorts (patients) Change P- value # cohorts (patients) Change P- value # cohorts (patients) Change P- value ICOAP 2 (42) -26.7 (-36.4 to -17.0) <0.001 2 (39) -29.4 (-36.6 to -22.2) <0.001 SF-36 PCS 2 (42) 7.8 (1.9 to 13.7) 0.009 2 (39) 6.1 (2.9 to 9.4) <0.001 SF-36 MCS 2 (42) -1.5 (-5.0 to 2.0) 0.41 2 (39) 0.5 (-2.8 to 3.8) 0.76 Knee flexion 3 (62) 2.4 (-1.0 to 5.7) 0.16 2 (40) 1.4 (-2.0 to 4.9) 0.42 MRI % denuded bone 1 (20) -17.3 (-26.5 to -8.1) <0.001 1 (20) -13.9 (-23.3 to -4.5) 0.004 1 (20) -5.7 (-15.6 to -5.2) 0.30 1 (16) ~5 0.010