Mylène Jansen

308 Chapter 15 The baseline characteristics of the 3 patient groups are shown in Table 1. KJD TKA patients had a higher age than HTO patients, and a higher KLG than KJD HTO and HTO patients. There were no statistically significant differences between KJD HTO and HTO. Table 1 : Baseline parameters of the 3 patient groups KJD TKA (n=8) KJD HTO (n=8) HTO (n=17) P- value Age (years) 57.8 (6.3) 50.9 (7.7) 48.9 (6.3) 0.014 BMI (kg/m 2 ) 26.9 (3.7) 27.7 (3.9) 26.7 (2.8) 0.785 Male sex, n (%) 4 (50) 6 (75) 12 (71) 0.530* Medial MAC, n (%) 6 (75) 8 (100) 8 (100) 0.034* Kellgren-Lawrence, n (%) - Grade 0 - Grade 1 - Grade 2 - Grade 3 - Grade 4 0 (0) 0 (0) 0 (0) 3 (38) 5 (63) 0 (0) 1 (13) 1 (13) 6 (75) 0 (0) 0 (0) 2 (12) 7 (41) 7 (41) 1 (4) 0.002* Baseline T2 relaxation times (ms) MAC tibia 48.1 (2.8) 47.4 (4.1) 47.9 (4.8) 0.932 MAC femur 55.0 (2.4) 53.7 (1.9) 54.9 (3.3) 0.571 LAC tibia 43.1 (2.3) 40.3 (3.2) 41.4 (3.5) 0.231 LAC femur 52.8 (2.4) 52.0 (3.0) 53.4 (4.9) 0.778 Baseline volumes (mm 3 ) MAC tibia 876 (285) 1496 (502) 1432 (466) 0.011 MAC femur 2074 (289) 2967 (712) 2802 (636) 0.010 LAC tibia 1962 (632) 2074 (523) 2022 (282) 0.882 LAC femur 3776 (1352) 3745 (774) 3463 (700) 0.646 Mean and standard deviation or n (%) are shown. P- values are calculated with 1-way ANOVA, with post-hoc Tukey HSD tests in case of statistical significance (bold p- values; p< 0.05), or chi-square tests (indicated with *). All statistically significant differences were between KJD TKA and HTO (age and medial MAC) or KJD TKA and both other groups. There were no statistically significant differences between KJD HTO and HTO. HTO: high tibial osteotomy; KJD HTO : knee joint distraction (KJD) patients with indication HTO; KJD TKA : KJD patients with indication total knee arthroplasty; LAC: least affected compartment; MAC: most affected compartment. T2-mapping results after treatment For both T2 relaxation times and volumes, ICC values showed good (all femur ICCs) or excellent (all tibia ICCs) agreement between the observers (Supplementary Table S1). Baseline T2 times and volumes are shown in Table 1. There were no statistically significant differences between the groups in T2 times. The KJD TKA group showed significantly lower volumes for the MAC tibia and femur than the KJD HTO and HTO groups. Changes in T2 relaxation time in the 3 separate groups are shown in Figure 2 (baseline is set to 0). The KJD TKA group did not show statistically significant changes over time (all p> 0.1), but