Mylène Jansen

Cartilage collagen structure after KJD and HTO using T2-mapping 309 15 did show a trend of a 1-year increase followed by a slight decrease (for the MAC) or plateau (for the LAC) between 1 and 2 years. The KJD HTO group showed an increase in T2 times, which was statistically significant for all regions (all p< 0.025) except the LAC femur ( p= 0.054). HTO patients showed a significant T2 time increase in all regions (all p< 0.006). There were no significant differences between groups (all p> 0.08). Figure 2 : Baseline-corrected T2 relaxation times for the 3 patient groups: patients indicated for total knee arthroplasty (TKA) and treated with knee joint distraction (KJD), patients indicated for high tibial osteotomy (HTO) and treated with KJD, and patients indicated for and treated with HTO. Changes are split per compartment: (A) the tibia of the most affected compartment (MAC), (B) the femur of the MAC, (C) the tibia of the least affected compartment (LAC), (D) the femur of the LAC. * indicates statistically significant changes ( p< 0.05), for the KJD groups calculated with repeated measures ANOVA and for the HTO group calculated with paired t -tests. Changes in segmented cartilage volumes in the 3 groups are shown in Figure 2 (baseline is set to 0). Only the KJD TKA group showed significant volume increases in the MAC, statistically significant for the tibia ( p= 0.004) but not the femur ( p= 0.052). The other groups did not show clear volume changes (all p≥0.1). The changes in MAC tibia volume were significantly different between KJD TKA and KJD HTO ( p= 0.029), but not when corrected for KLG ( p= 0.457), which was significantly different between the two.