Mylène Jansen

310 Chapter 15 Pearson correlations between 1- or 2-year changes in T2 values and volumes were not statistically significant for any of the compartments or groups (all p> 0.09), except for the 2-year LAC femur changes in the HTO group ( R= -0.660; p= 0.004). Figure 3 : Baseline-corrected segmented volumes for the 3 patient groups: patients indicated for total knee arthroplasty (TKA) and treated with knee joint distraction (KJD), patients indicated for high tibial osteotomy (HTO) and treated with KJD, and patients indicated for and treated with HTO. Changes are split per compartment: (A) the tibia of the most affected compartment (MAC); (B) the femur of the MAC; (C) the tibia of the least affected compartment (LAC); (D) the femur of the LAC. * indicates statistically significant changes ( p< 0.05), for the KJD groups calculated with repeated measures ANOVA and for the HTO group calculated with paired t -tests. Influence of baseline characteristics Combining the MAC and LAC, in the KJD TKA group, only age had a significant positive effect on the change in T2 relaxation times in the tibia (B=0.310, p= 0.023) and baseline T2 time had a significant negative effect on the change in the femur (B=-0.629, p= 0.019). In the KJD HTO group, none of the baseline characteristics or T2 values had a statistically significant influence. In the HTO group, BMI ( B =-0.365, p= 0.002) and baseline T2 time ( B =-0.234, p= 0.015) had a significant negative effect on the change in the femur.