Mylène Jansen

338 Chapter 16 measurement of this response in SF as both possible and informative. 22,41 Ways of finding associations with a positive outcome to distraction are currently limited. 13 These observations show the potential to define biomarker(s) associated with positive clinical responses to this and similar interventions aiming to off-load the joint surfaces. 42,43 Biomarker stratification, identifying individuals most likely to respond in clinical trials or usual care would increase the utility of this already apparently cost-effective intervention. 44 Experimental studies of joint distraction represent a novel way of identifying potential regenerative pathways that drive intrinsic connective tissue repair; these pathways might be amenable to augmentation, by pharmacological or other means to treat symptomatic OA.