Mylène Jansen

SF biomarker changes upon KJD 345 16 Supplementary Table 2 : Regression coefficients and confidence intervals of the association of change in markers over distraction period with change in KOOS 4 over 3 months, 6 months and 12 months (data are also shown by forest plot in Figure 4A) Period Analyte Coefficient 95%CI R 2 P- value 3 months Activin A -0.001 -0.002 to <0.001 0.39 0.01 LTBP2 0.002 -0.002 to 0.006 0.07 0.29 TGF β -1 0.001 <0.001 to 0.002 0.37 0.01 FGF-2 0.021 0.005 to 0.038 0.34 0.01 TIMP-1 <0.001 <0.001 to <0.001 <0.01 0.96 TSG-6 <0.001 <0.001 to <0.001 <0.01 0.89 IL-6 <0.001 -0.017 to 0.016 <0.01 0.96 MCP-1 0.034 0.003 to 0.064 0.27 0.03 IL-8 0.064 -0.028 to 0.156 0.13 0.16 MMP3 <0.001 <0.001 to <0.001 0.05 0.41 6 months Activin A -0.002 -0.003 to <0.001 0.36 0.02 LTBP2 0.002 -0.004 to 0.009 0.05 0.42 TGF β -1 0.002 <0.001 to 0.003 0.35 0.02 FGF-2 0.030 0.004 to 0.057 0.32 0.03 TIMP-1 <0.001 <0.001 to <0.001 <0.01 0.92 TSG-6 <0.001 <0.001 to <0.001 0.03 0.55 IL-6 0.007 -0.017 to 0.031 0.03 0.55 MCP-1 0.052 -0.005 to 0.098 0.31 0.03 IL-8 0.087 -0.048 to 0.221 0.13 0.19 MMP3 <0.001 <0.001 to <0.001 <0.01 0.81 12 months Activin A -0.002 -0.006 to 0.002 0.08 0.34 LTBP2 -0.002 -0.007 to 0.003 0.05 0.45 TGF β -1 -0.001 -0.002 to 0.001 0.05 0.48 FGF-2 -0.001 -0.025 to 0.024 <0.01 0.95 TIMP-1 <0.001 <0.001 to <0.001 0.02 0.62 TSG-6 <0.001 <0.001 to <0.001 0.05 0.45 IL-6 0.005 -0.014 to 0.023 0.03 0.59 MCP-1 -0.013 -0.062 to 0.036 0.03 0.58 IL-8 0.277 -0.096 to 0.651 0.20 0.13 MMP3 <0.001 <0.001 to <0.001 0.02 0.61 FGF-2: basic fibroblast growth factor; IL-6: interleukin 6; IL-8: interleukin 8; KOOS 4 : Knee injury and osteoarthritis outcome score-4; LTBP2: latent-transforming growth factor beta-binding protein 2; MCP-1: monocyte chemoattractant protein 1; MMP3, matrix metalloproteinase-3; TGF β -1: transforming growth factor beta 1; TIMP-1: tissue inhibitor of metalloproteinases 1; TSG-6: TNF stimulated protein-6.