Mylène Jansen

Osteophyte formation after KJD and HTO 357 17 did not have a standardized baseline radiograph, leaving 58 KJD patients for analysis, of whom 20 in the KJD HTO group. Of the HTO patients, 1 was excluded before treatment due to anxiety while 4 patients were lost to follow-up due to comorbidities. Five did not have standardized radiographs at both baseline and 2 years follow-up, leaving 36 HTO patients. In CHECK, 30 patients received a TKA during the 10-year follow-up, 14 of whom had a TKA in both knees, giving a total of 44 knees to be compared to the KJD patients. Three of the 20 patients with SF aspirations did not have both a baseline and follow-up radiograph available, leaving 17 SF patients. The baseline characteristics of all groups are shown in Table 1. Table 1 : Baseline characteristics of the different patient groups KJD (n=58) KJD HTO (n=20) HTO (n=36) CHECK (n=44) SF (n=17) Age (years) 51.4 (8.0) 51.2 (5.8) 49.1 (6.5) 64.0 (4.3) 53.8 (4.7) Male sex, n (%) 34 (59) 15 (75) 23 (64) 5 (11) 10 (59) BMI (kg/m 2 ) 28.0 (3.4) 27.4 (3.3) 27.0 (3.5) 29.4 (4.6) 29.0 (3.3) Kellgren-Lawrence grade, n (%) - Grade 0 - Grade 1 - Grade 2 - Grade 3 - Grade 4 0 (0) 8 (14) 9 (16) 28 (48) 13 (22) 0 (0) 5 (25) 4 (20) 10 (50) 1 (5) 1 (3) 4 (11) 10 (28) 18 (50) 3 (8) 2 (5) 18 (41) 16 (36) 8 (18) 0 (0) 0 (0) 0 (0) 2 (12) 7 (41) 8 (47) Mean and standard deviation or n (%) are given. BMI: body mass index; KJD: all knee joint distraction patients with available osteophyte measurements; KJD HTO : subgroup of KJD patients who were included in the KJD versus HTO clinical trial; HTO: high tibial osteotomy patients from the KJD versus HTO clinical trial; CHECK: untreated knee osteoarthritis patients from the Cohort Hip & Cohort Knee trial who received a total knee arthroplasty during follow-up; SF: KJD patients from a separate clinical study who underwent synovial fluid aspirations. Changes after knee joint distraction As shown in Table 2, the total WOMAC showed significant improvement 2 years after KJD (+28.1; 95%CI 22.7–33.4; p< 0.001), as did its subscales. The mean MAC radiographic JSW was significantly increased at 2 years as well (+0.66; 0.36–0.97; p< 001).