Mylène Jansen

38 Chapter 2 Supplementary results Comparison with control groups Primary outcome measures The change in VAS pain (Figure S8) was better for both TKA and HTO compared to KJD at both time points (all p< 0.02), with the MD varying between -16.6 (HTO, 2 years) and -19.5 (TKA, 2 years). The original 2-year article (Jansen 2019a) corrects the comparisons for baseline values, which results in no statistically significant difference in 2-year VAS pain change between KJD and HTO ( p= 0.120). The 1-year comparison between KJD and HTO (Van der Woude 2017b) was also reported not to be statistically significantly different (no p- value given). The change in total KOOS (Figure S9) after 2 years was significantly better for TKA than KJD (MD=-14.6; p= 0.001) while there was no significant 1-year difference between TKA and KJD and no significant 1- and 2-year difference between HTO and KJD, with MDs between -8.0 (HTO, 1 year) and -10.0 (TKA, 1 year) and all p> 0.05. The mean JSW of the MAC (Figure S10) is compared between KJD and HTO after 1 and 2 years. There was no significant difference after either 1 (MD=0.40; p= 0.099) or 2 (MD=-0.05; p= 0.853) years. Compared to the OAI, the mean JSW showed significantly better results 5 years after KJD (MD=1.06; p< 0.001). Treatment with KJD, microfracture and debridement showed a greater increase in mean JSW after 4 – 7 years than microfracture and debridement alone (MD=2.10; p< 0.001). The mean MAC cartilage thickness (Figure S11) shows a significantly better result over 5 years for KJD patients than the OAI (MD=0.48; p< 0.001). For HTO patients from the MRI RCT sub-cohort, a cartilage thickness decrease of around 0.2mm is reported ( p< 0.05), and the thickness increase observed in KJD patients is significantly better than HTO ( p< 0.01). Other outcome measures The 2-year SF-36 PCS change was better for TKA than KJD (MD=-12.6; 95%CI -18.9– -6.3; p< 0.001), while the 1-year change in knee flexion was better for KJD than TKA (MD=7.0; 95%CI 1.0–13.0; p= 0.027). The SF-36 PCS change was significantly better for HTO over 1 (MD=-5.0; 95%CI -9.3 to -0.8; p= 0.031) and 2 (MD=-5.4; 95%CI -10.1 to -0.7; p= 0.034) years, while the 1-year change in knee flexion was better for KJD than HTO (MD=6.0; 95%CI 0.5–11.5; p= 0.042). Adding KJD to microfracture and debridement improved stair climbing ( p< 0.000). De decrease (improvement) in denuded bone was significantly more for KJD than HTO ( p< 0.01).