Mylène Jansen

CONTENTS Chapter 1 General introduction 9 Part I: Clinical outcome and patient experience Chapter 2 Knee joint distraction as treatment for osteoarthritis results in clinical and structural benefit: A systematic review and meta-analysis of the limited number of studies and patients available 19 Chapter 3 Initial tissue repair predicts long-term clinical success of knee joint distraction as treatment for knee osteoarthritis 45 Chapter 4 Knee joint distraction compared with high tibial osteotomy and total knee arthroplasty: Two-year clinical, radiographic, and biochemical marker outcomes of two randomized controlled trials 59 Chapter 5 Return to sport and work after randomization for knee distraction versus high tibial osteotomy: Is there a difference? 85 Chapter 6 Knee joint distraction in regular care for treatment of knee osteoarthritis: A comparison with clinical trial data 109 Chapter 7 User-friendliness of a novel dedicated knee joint distraction device: Experiences from clinical practice 129 Chapter 8 Reduction of pin tract infections during external fixation using cadexomer iodine 155 Chapter 9 Prospective one-year follow-up of clinical efficacy of knee distraction as treatment for knee osteoarthritis by use of the KneeReviver 167 Part II: Joint processes and working mechanisms Chapter 10 Joint distraction for osteoarthritis: Clinical evidence and molecular mechanisms 187 Chapter 11 Performance of Knee Image Digital Analysis of radiographs of patients with severe end-stage knee osteoarthritis 213