Mylène Jansen

68 Chapter 4 KJD versus TKA The TKA group showed statistically significantly greater improvements than the KJD TKA group for most of the clinical parameters (Table 3), including the total KOOS and most of its subscales (all p< 0.035), the VAS pain ( p= 0.016), the EQ-5D ( p= 0.023), and the SF-36 PCS ( p< 0.001). There was no significant difference for the total WOMAC ( p= 0.066), WOMAC stiffness ( p= 0.098), KOOS stiffness ( p= 0.212), the ICOAP ( p= 0.089), and ICOAP subscales (both p> 0.167). As the change in WOMAC over 2 years was on average considerably more than 15 points and with that clinically significant, this change in WOMAC was not clinically relevantly different between both treatments (Δ38.9 (95%CI 28.8–48.9) points versus Δ42.1 (34.5–49.7)). The total WOMAC score at 2 years was 79.3 (70.9–87.8) for the KJD TKA group and 87.4 (83.4–91.4) for the TKA group, indicating no clinically significant difference cross- sectionally at 2 years in the primary outcome. Table 3 : Two-year changes in clinical and structural parameters KJD vs TKA KJD vs HTO KJD TKA (n=19) TKA (n=34) P- value KJD HTO (n=20) HTO (n=41) P- value WOMAC (0–100) Total 38.9 * (28.8 to 48.9) 42.1 * (34.5 to 49.7) 0.066 26.8 * (17.1 to 36.6) 34.4 * (28.0 to 40.7) 0.413 Stiffness 25.8 * (14.2 to 37.4) 32.7 * (25.0 to 40.4) 0.098 16.2 * (5.2 to 27.3) 24.5 * (18.0 to 31.0) 0.337 Pain 28.4 * (18.5 to 38.4) 43.6 * (37.0 to 50.1) 0.008 23.6 * (15.5 to 31.8) 31.8 * (25.4 to 38.3) 0.408 Func- tion 26.3 * (17.0 to 35.6) 40.9 * (35.7 to 46.2) 0.016 21.5 * (13.6 to 29.5) 28.9 * (23.0 to 34.7) 0.318 KOOS (0–100) Total 28.7 * (20.4 to 37.1) 43.3 * (38.7 to 47.9) 0.002 21.6 * (14.4 to 28.8) 30.0 * (25.0 to 35.1) 0.109 Symp- tom 28.3 * (20.5 to 36.0) 33.6 * (27.5 to 39.6) 0.212 16.7 * (10.2 to 23.3) 22.6 * (17.7 to 27.5) 0.276 Pain 29.8 * (20.3 to 39.3) 47.9 * (42.3 to 53.5) 0.001 25.7 * (17.6 to 33.8) 32.5 * (27.0 to 38.1) 0.347 Func- tion 31.0 * (23.0 to 38.9) 42.5 * (38.2 to 46.9) 0.034 21.6 * (13.6 to 29.6) 28.9 * (23.1 to 34.8) 0.317 Sport 28.3 * (14.6 to 42.0) 49.2 * (41.0 to 57.5) 0.007 25.7 * (15.1 to 36.3) 33.8 * (25.3 to 42.3) 0.314 QOL 26.3 * (13.7 to 38.8)* 44.5 * (36.4 to 52.6) 0.015 17.7 * (10.1 to 25.2) 32.2 * (25.4 to 39.0) 0.013 VAS (100–0) Pain -31.9 * (-48.5 to -15.4) -55.9 * (-64.3 to -47.6) 0.016 -21.4 * (-33.3 to -9.8) -38.5 * (-46.2 to -30.7) 0.120 EQ-5D (0–1) Index 0.10 (-0.02 to 0.22) 0.27 * (0.16 to 0.38) 0.023 0.16 * (0.06 to 0.26) 0.11 * (0.04 to 0.19) 0.564