Mylène Jansen

Two-year results of KJD compared with HTO and TKA 69 4 Table 3 : Two-year changes in clinical and structural parameters ( continued ) KJD vs TKA KJD vs HTO KJD TKA (n=19) TKA (n=34) P- value KJD HTO (n=20) HTO (n=41) P- value ICOAP (100–0) Con- stant -28.0 * (-35.7 to -20.3) -39.2 * (-47.3 to -31.1) 0.089 -19.8 * (-28.8 to -10.7) -22.9 * (-30.7 to -15.1) 0.770 Inter- mittent -26.0 * (-33.8 to -18.2) -35.5 * (-42.4 to -28.7) 0.284 -17.1 * (-26.6 to -9.8) -22.3 * (-28.9 to -15.7) 0.669 Com- bined -26.9 * (-34.5 to -19.4) -37.2 * (-44.2 to -30.2) 0.168 -18.3 * (-27.3 to -9.2) -22.6 * (-28.9 to 16.2) 0.673 SF-36 (0–100) PCS 5.3 (-0.5 to 11.1) 17.9 * (14.6 to 21.2) <0.001 6.5 * (2.6 to 10.4) 11.9 * (8.9 to 14.9) 0.051 MCS 0.4 (-6.0 to 6.7) -0.6 (-6.6 to 5.3) 0.728 1.0 (-2.9 to 4.9) -1.1 (-4.5 to 2.3) 0.468 Flexion (°) Knee - - - 1.4 (-2.3 to 5.0) -2.0 (-5.0 to 1.0) 0.254 JSW (mm) Mini- mum 0.90 * (0.22 to 1.57) - - 0.94 * (0.50 to 1.37) 0.62 * (0.31 to 0.92) 0.233 Mean 0.99 * (0.32 to 1.65) - - 0.83 * (0.34 to 1.32) 0.88 * (0.58 to 1.18) 0.884 Western Ontario and McMaster Universities Osteoarthritis index (WOMAC), Knee injury and Osteoarthritis Outcome Score (KOOS), Visual Analogue Scale (VAS), EuroQol (EQ)-5D, intermittent and constant osteoarthritis pain score (ICOAP), and Short Form (SF)-36 clinical scores and sub scores (PCS: Physical Component Score and MCS: Mental Component Score), maximum knee flexion and mean and minimum joint space width (JSW), for each of the 4 patient groups (total knee arthroplasty (TKA), knee joint distraction (KJD) patients indicated for TKA (KJD TKA ), high tibial osteotomy (HTO) and KJD patients indicated for HTO (KJD HTO ). Mean and 95% confidence intervals are given and ranges from worst to best are indicated for the clinical parameters. Statistically significant change ( p< 0.05) compared to baseline is indicated with *, calculated with paired t -tests. Changes between patient groups from each separate trial (KJD/TKA and KJD/HTO) are compared and corrected for baseline values using linear regression, bold p- values indicate statistical significance. Flexion parameters were not measured at 2 years in the KJD TKA and TKA groups. KJD versus HTO The HTO and KJD HTO groups showed no statistically significant differences in change from baseline (Table 3), except for the KOOS quality of life subscale, where HTO showed a greater improvement ( p= 0.013). The improvements over 2 years follow-up in total WOMAC score as primary outcome was clinically relevant for both treatment arms, exceeding the 15 points, whereas the change over 2 years was not clinically relevantly different between both treatments (Δ26.8 (95%CI 17.1–36.6) points versus Δ34.4 (28.0–40.7) points. With a total WOMAC score of 79.4 (70.9–87.8) for the KJD HTO group and 80.8 (75.7–85.9) for the HTO group at 2 years, the cross-sectional difference at 2 years in the primary outcome was not clinically relevant either.