Mylène Jansen

Two-year results of KJD compared with HTO and TKA 79 4 15 points and with that clinically significant, this change in WOMAC was not clinically relevantly different between both treatments: Δ30.4 (95%CI 23.0–37.9) points versus Δ42.4 (38.1–46.8). The total WOMAC score at 2 years was 81.0 (73.3–88.7) for the KJD TKA group and 88.1 (84.2–91.9) for the TKA group, indicating no clinically significant difference cross- sectionally at 2 years in the primary outcome. KJD versus HTO The improvements over 2 years follow-up in total WOMAC score as primary outcome was clinically relevant for both treatment arms, exceeding the 15 points, whereas the change over 2 years was not clinically relevantly different between both treatments: Δ21.6 (95%CI 13.8– 29.4) points versus Δ29.2 (23.6–34.8) points. Radiographic evaluation KJD versus TKA In the KJD TKA group, the minimum JSW increased significantly from 0.69 (SEM 0.33) mm at baseline to 1.58 (0.28) at 2 years ( p= 0.013) while the mean JSW of the MAC increased from 1.89 (0.51) to 2.87 (0.44) at 2 years ( p= 0.006), as shown in Figure 3. (Note: The minimum and mean JSW changes are correct in the table and figure, but the numbers in the text are not correct for the KJD TKA group.) Tables and figure Amended versions of Table 2, Table 3, and Figure 1 are included. In both tables, changes were made to the WOMAC, VAS pain, and ICOAP parameters, as indicated in italics. In Figure 1, the most important changes are seen in 1B and 1D, including a change in p -values for differences between groups, which in the case of KJD versus TKA is now significant. On behalf of all authors, Sincerely, Mylène Jansen and Floris Lafeber